Test
1807NRS Safe Administration of Medications 2
Preguntas del test (30)
1Pharmacodynamics involves the study of following EXCEPT:
- ABiological and therapeutic effects of drugs
- BAbsorption and distribution of drugs
- CMechanisms of drug action
- DDrug interactions
2Pharmacodynamics involves the study of following?
- AMechanisms of drug action
- BBiotransformation of drugs in the organism
- CDistribution of drugs in the organism
- DExcretion of drug from the organism
3Pharmacodynamics involves the following?
- AInformation about main mechanisms of drug absorption
- BInformation about unwanted effects
- CInformation about biological barriers
- DInformation about excretion of a drug from the organism
4Pick out the answer which is the most appropriate to the term “receptor”
- AAll types of ion channels modulated by a drug
- BEnzymes of oxidizing-reducing reactions activated by a drug
- CActive macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect
- DCarriers activated by a drug
5What does “affinity” mean?
- AA measure of how tightly a drug binds to plasma proteins
- BA measure of how tightly a drug binds to a receptor
- CA measure of inhibiting potency of a drug
- DA measure of bioavailability of a drug
6Target proteins which a drug molecule binds are:
- AOnly receptors
- BOnly ion channels
- COnly carriers
- DAll answers are correct
7An agonist is a substance that:
- AInteracts with the receptor without producing any effect
- BInteracts with the receptor and initiates changes in cell function, producing various effects
- CIncreases concentration of another substance to produce effect
- DInteracts with plasma proteins and doesn’t produce any effect
8If an agonist can produce maximal effects and has high efficacy it’s called:
- APartial agonist
- BAntagonist
- CAgonist-antagonist
- DFull agonist
9If an agonist can produce submaximal effects and has moderate efficacy it’s called:
- APartial agonist
- BAntagonist
- CAgonist-antagonist
- DFull agonist
10An antagonist is a substance that:
- ABinds to the receptors and initiates changes in cell function, producing maximal effect
- BBinds to the receptors and initiates changes in cell function, producing submaximal effect
- CInteracts with plasma proteins and doesn’t produce any effect
- DBinds to the receptors without directly altering their functions
11A competitive antagonist is a substance that:
- AInteracts with receptors and produces submaximal effect
- BBinds to the same receptor site and progressively inhibits the agonist response
- CBinds to the nonspecific sites of tissue
- DBinds to one receptor subtype as an agonist and to another as an antagonist
12The substance binding to one receptor subtype as an agonist and to another as an antagonist is called:
- ACompetitive antagonist
- BIrreversible antagonist
- CAgonist-antagonist
- DPartial agonist
13Irreversible interaction of an antagonist with a receptor is due to:
- AIonic bonds
- BHydrogen bonds
- CCovalent bonds
- DAll answers are correct
14Mechanisms of transmembrane signaling are the following EXCEPT:
- ATransmembrane receptors that bind and stimulate a protein tyrosine kinase
- BGene replacement by the introduction of a therapeutic gene to correct a genetic effect
- CLigand-gated ion channels that can be induced to open or close by binding a ligand
- DTransmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger
15Tick the second messenger of G-protein-coupled (metabotropic) receptor:
- AAdenylyl cyclase
- BSodium ions
- CPhospholipase C
- DcAMP
16Tick the substance which changes the activity of an effector element but doesn’t belong to second messengers:
- AcAMP
- BcGMP
- CG–protein
- DCalcium ions
17Give the definition for a therapeutical dose:
- AThe amount of a substance to produce the minimal biological effect
- BThe amount of a substance to produce effects hazardous for an organism
- CThe amount of a substance to produce the required effect in most patients
- DThe amount of a substance to accelerate an increase of concentration of medicine in an organism
18Pick out the correct definition of a toxic dose:
- AThe amount of substance to produce the minimal biological effect
- BThe amount of substance to produce effects hazardous for an organism
- CThe amount of substance to produce the necessary effect in most of patients
- DThe amount of substance to fast creation of high concentration of medicine in an organism
19Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly?
- ARefractoriness
- BCumulative effect
- CTolerance
- DTachyphylaxis
20What term is used to describe a decrease in responsiveness to a drug which develops in a few minutes?
- ARefractoriness
- BCumulative effect
- CTolerance
- DTachyphylaxis
21Idiosyncratic reaction of a drug is:
- AA type of hypersensitivity reaction
- BA type of drug antagonism
- CUnpredictable, inherent, qualitatively abnormal reaction to a drug
- DQuantitatively exaggerated response
22Characteristic unwanted reaction which isn’t related to a dose or to a pharmacodynamic property of a drug is called:
- AIdiosyncrasy
- BHypersensitivity
- CTolerance
- DTeratogenic action
23If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of
the drugs given individually, it is called as:- AAntagonism
- BPotentiation
- CAdditive effect
- DNone of the answers are correct
24What phenomenon can occur in case of using a combination of drugs?
- ATolerance
- BTachyphylaxis
- CAccumulation
- DSynergism
25What is the type of drug-to-drug interaction which is the result of interaction at receptor, cell, enzyme or organ level?
- APharmacodynamic interaction
- BPhysical and chemical interaction
- CPharmaceutical interaction
- DPharmacokinetic interaction
26What is the type of drug-to-drug interaction which is connected with processes of absorption, biotransformation,
distribution and excretion?- APharmacodynamic interaction
- BPhysical and chemical interaction
- CPharmaceutical interaction
- DPharmacokinetic interaction
27The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called?
- ATachyphylaxis
- BSensibilization
- CAbstinence syndrome
- DIdiosyncrasy
28Tolerance and drug resistance can be a consequence of:
- ADrug dependence
- BIncreased metabolic degradation
- CDepressed renal drug excretion
- DActivation of a drug after hepatic first-pass
29Tolerance and drug resistance can be a consequence of:
- AChange in receptors, loss of them or exhaustion of mediators
- BIncreased receptor sensitivity
- CDecreased metabolic degradation
- DDecreased renal tubular secretion
30Tolerance develops because of:
- ADiminished absorption
- BRapid excretion of a drug
- CBoth answers are correct
- DNo answer is correct
Información
- Descripción
- Nursing Test sobre 1807NRS Safe Administration of Medications 2, creado por Kathleen Jackson el 01/10/2017.
- Autor
- Kathleen Jackson
- Idioma
- English
- Visitas
- 159
- Etiquetas
- Valoración
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