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Learning I
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- 1Non-associative learningRelatively permanent change in response
Habituation
Sensitisation - 2HabituationLearning to ignore a stimulus that has meaning (text alert)
- 3SensitisationStrong stimulus resulting in exaggerated response to all subsequent stimuli
- 4Graphlook at your notes
- 5Classical conditioningAssociating an unconditioned stimulus that causes a measurable response to a conditioned stimulus that doesn't normally evoke this response
- 6What's very important in classical conditioning?Timing of CS and US
- 7Instrumental conditioningLearning to associate a cue with a meaningful stimulus
- 8What's important in instrumental conditioning?Motivation
Timing - 9Non-associative learning in Aplysia is tested by looking at:Gill withdrawal reflex
- 10What is the stimulus?Spraying siphon with water
- 11Response arc for thisSiphon skin
Sensory neuron
Motor neuron L7
Gill muscle - 12Proof that habituation occurs at the synapse levelMotor L7 neuron EPSPs decline over time
- 13How can aplysia be conditioned to exhibit sensitisation?Give strong head shock stimulus
- 14MOA for this arcL29 neuron releases serotonin onto receptor of pre-synaptic terminal of the sensory neuron
Binds to 5-HT R, a GPCR
G protein + adenylyl cyclase
^ cAMP = open ion channels
and goes on to + PKA
PKA phosphorylates K channels
K channels close - prolonging AP
More Ca++ in
More quanta released - 15What do we know from invertebrate studies? (3)1. Modifications in synaptic transmission can result in learning and memory
2. Changes in neuronal electrical activity can modify IC 2' Messenger pathways
3. Alternations in existing synaptic proteins can result in learning and memory
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- Fichas sobre Learning I, creado por J yadonknow el 10/05/2018.
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- J yadonknow
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