1099598
Description
Flashcards by jenny schneider, updated more than 1 year ago
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Created by jenny schneider
almost 10 years ago
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| Question | Answer |
| What is the process called when a solid goes from solid state to gaseous state (no liquid state in between) | sublimation |
| Define bioavailability | The fraction of the dose administered that reaches the systemic circulation |
| What are three sources of loss of a drug when it is given orally that will result in a bioavailability less than 1 | not absorbed from GIT (or broken down/complexed in GIT) metabolised in gut wall first pass metabolism in liver |
| What do the letters in the acronym LADME stand for? | Liberation Absorption Distribution Metabolism Excretion |
| True of False A drug must be in solution in gut before it can be absorbed | True |
| What are FOUR different receptor types that are drug targets | ion channels extracellular enzymes intracellular receptors Transmembrane linked to G proteins Transmembrane with enzymatic cytosol domain cell surface adhesion |
| Define pharmacokinetics | time course of drug in the body (what body does to the drug) |
| Define pharmaceutics | science of dosage form design |
| define pharmacodynamics | study of response observed when dose is administered (concentration-effect relationship) |
| Which route of administration has a bioavailability of 1? | IV |
| List some physicochemical properties of a drug that can influence dosage form design and also pharmacokinetics of drug | pKa, particle size, partition coefficient, pH stability profile, polymorphism, hygroscopicity, solubility, MW and molecular structure |
| Which of the following routes of administration will have an absorption step? oral, IV, rectal, SC, IM, transdermal | all except IV where all drug is immediately placed in systemic circulation |
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