13054312
Description
Flashcards by J yadonknow, updated more than 1 year ago
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Created by J yadonknow
about 6 years ago
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| Question | Answer |
| Kidney 7 major functions | Water balance (vol reg.) Osmotic balance Ionic balance pH balance BP regulation Waste excretion Hormone production |
| 4 major principles of urine production | 1. Filtration 2. Re-absorption 3. Secretion 4. Excretion (Micturition) |
| Role of glomerulus in filtration | Afferent arteriole to glomerulus leaves via efferent arteriole inside glomerulus is glomerular tuft |
| How is a material xchange maintained in glomerulus | constant vasoactivity |
| What are the pressures? | HSP of fluid against wall |
| How does ultrafiltration occur? | 3 layer filtration barrier endothelium cell basement process foot process of podocyte |
| What is glomerular filtration rate? | 120mL/min (180L/day) How much blood is passed through your glomerulus per minute |
| What is the BM selective against? | Charge + size |
| What is clearance? | Ability of kidney to filtrate blood |
| Work out Net HSP | Glom. capillary p - intracapsular p |
| Work out net filtration pressure | Net HSP - COP |
| What are JGA cells? | Cells that line afferent arteriole sense BF into kidney and produce renin |
| What allows them to do this | Macula densa cells, which detect flow in the tubule lumen |
| Why are tubule epithelial cells unique? | Relatively impermeable due to LBL comp. TJ Have polarity |
| What is meant by polarity | proteins can be directed to either apical or basolateral membrane |
| Function of PCT epi cells | large microvilli major site of reabsorption secretion of toxins here |
| DL fucntion | very permeable to water due to lack of tight junctions water reabsorption |
| AL function | Reabsorption of ions |
| DCT | Reabsorption + secretion maintain acid-base balance |
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