13065101
Description
Flashcards by J yadonknow, updated more than 1 year ago
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Created by J yadonknow
about 6 years ago
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| Question | Answer |
| Types of receptors (IGE IRNI) | Ion channel-linked (ms) G protein coupled (s-hours) Enzyme-linked (s-hours) Intrinsic Enzyme activity Recruit enzymes from cytoplasm Nuclear Ionotropic ^ hours |
| Transporters | Uniporter - substance 1 direction Symporter - 2 Δ sub. 1 direction Antiporter - 2 Δ sub. Δ directions |
| Ion channel-linked R | Act as gates L-binding induces conf Δ, opening the gate |
| Pharma modding of ICL | Channel blockers (physical block) Channel modulators (bind channel, enhance/inhibit opening.) |
| GPCRs | Most common Trimeric G protein + coupled effector molecule 7 transmem helices |
| G protein binding site | 3rd cytoplasmic loop Cytoplasmic C-terminal tail, sites available for +Pi |
| G proteins | Guanine nucleotide binders |
| Forms of G proteins | Monomeric i.e. Ras Trimeric (alpha,beta,gamma) |
| Trimeric | Only alpha SU can bind Guanine Linked to PCM by lipid chain |
| GPCR binding (4) | 1. Binding of L induces conf. Δ in R 2. + R binds to Gα SU 3. Binding induces conf. Δ in Gα 4. Bound GDP dissociates + is replaced by GTP. 5. Gα dissociates from Gβ/Gγ 6. L dissociated from R, Gα binds and + Effector. 7. Hydrolysis of GTP->GDP causes Gα to dissociate from Eff, re-associate with Gβ/Gγ. SWAPS GTP FOR GDP, DOESN'T CONVERT. |
| GPCR signal termination by R desensitisation | Arrestin binds to +Pi form of GPCR Competes w/ G proteins for binding Promotes R interalisation via Clathrin-mediated endocytosis |
| Table of trimeric proteins | |
| Learn glycogen metabolism like day before | yah |
| cAMP level regulation using inhibitory hormone | An example of GPCR signalling PGE1/Adenosine inhibits adenylyl cyclase GalphaI binds to adenylyl cyclase and inhibits it |
| Maybe learn AcCh here | endothelial cells in BV to bring about smooth muscle relaxation |
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