Flashcards
Hormones IV
Cards in this deck (33)
- 1Plasma Ca2.2-2.6mM
- 2Calcium formsProtein bound - can't diffuse through membranes
Chelated/complexed - Phosphate/bicarbonate
Free -physiologically active - 3Plasma calcium controlNet absorption GIT
Net excretion kidney
Temporary storage Bone - 4OsteoblastSecretes collagen, hydroxyapatite, clast stimulating factors
- 5OsteoclastBone resorption
- 6OsteocyteEssential role in Ca X between ECF and bone
- 7Acute control of Plasma calciumMaintain constant free [Ca2+] by rapid X between ECF and Bone
- 8Chronic control of plasma calciumAdjust GIT absorption and urinary excretion
- 93 hormones controlPTH
1,25-Dihydroxycholecalciferol
Calcitinon - 10How does PT gland control?Monitors [Ca2+] in blood perfusing the glands
- 11What does removal cause?Fatal hypocalcaemia
- 12PTHPeptide hormone
stored in chief cells - 13t1/2?5 minutes
- 14When released?In response to low plasma [Ca2+]
- 15Where exert effects?KBG
Mainly KB though - 16What does it do?^ reabsorption of Ca from urine
^ Expression of 1alpha-hydroxylase (which + Vit. D). - 17What are the effects on bone?^ clast activity indirectly = ^ resorption
- 18Draw hormone feedback cycleLow [Ca] -> PTG -> PTH -> Clast/Kidney reabsorption/Po4 excretion -> ^ Ca
- 19D2 name and sourceErgocalciferol, food supplements
- 20D3Cholcalciferol - diet + skin UV
- 21What are they converted to?1,25-DHCC
- 22Hormone feedback diagram of sunlight exposureSunlight
skin
7-dehydocholesterol
Liver
25-hydroxyvitamin D3
Kidney
1,25-DHCC
+Vit D - 23What type of hormone is vit D?Steroid
- 24Calcitriol MOA^ Ca transport protein in GIT
^ Ca uptake from GIT
Only mech. to ^ Ca stores - 25Used in what kind of treatment?Kidney failure patients can't make 1alpha-hydroxylase
- 26Effects on Kidney/bonedecrease urinary loss
^ Bone resorption rate by ^ ost + factor secretion - 27CalcitoninSecreted by C-cells (parafollicular cells) of TH gland
Minor importance in adults
decrease [Ca] free in plasma - 28Calcitonin MOAInhibits clast activity -direct effect
^ excretion of Ca+Po4 from kidneys - 29Hyperparathyroidism causesHypercalcaemia
- 30Vitamin D deficiency causesHypocalcaemia
- 31Cause of Primary hyperparathyroidismAutonomous PTH secretion
Increases serum Ca, decreases serum PO4 - 32Symptoms of Vitamin D deficiencyCalcification failure
Osteomalacia = soft bones in adults
Rickets in children - 33What does vitamin D deficinency lead to?Body sacrifices bone stores and causes a compensatory rise in PTH, doesn't lead to hypocalcaemia
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- User has deleted their subject information Flashcards on Hormones IV, created by Deleted user on 04/04/2018.
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- Created by J yadonknow · Apr 4, 2018
- Copied by J yadonknow · Apr 4, 2018
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