Flashcards
Immunology - Absite
Cards in this deck (41)
- 1What do helper T-Cells (CD4) release?IL-2, IL-4, IFN-gamma
- 2What type of hypersensitivity are Helper T-cells involved in?delayed type hypersensitivity
Type IV - 3IL-2 cause maturation of what type of cells?cytotoxic T cells
- 4IL-4 causes maturation of which cells?B-cells into plasma cells
- 5What does IFN-gamma activate?macrophages
- 6Action of Suppressor T cells (CD8)regulate CD4 and CD8 cells
- 7Action of Cytotoxic T cells (CD8)recognize and attack non-self antigens attached to MHC class I receptors (viral)
responsible for majority of liver injury d/t HepB - 8Effector cells in cell-mediated immunitymacrophages
cytotoxic T cells
natural kill cells - 9What do intradermal skin tests detect?cell-mediated immunity
takes 2-3days - 10What kinds of infections are associated with defect in cell-mediated immunity?intracellular pathogens (TB, viruses)
- 11Which immunoglobulin is secreted with reinfection?IgG
- 12MHC Class ICD8 activation
present on all nucleated cells
Single chain with 5 domains
Target for cytotoxic T cells - 13MHC class IICD4 activation
present on antigen presenting cells
2chains, 4domains each
APCs activate helper T cells
Stim. Ab formation - 14Natural Killer Cellsnot restricted by MHC, don't require previous exposure, don't require antigen presenting
Recognizes cells that lack self-MHC
immunosurveillance for cancer - 15IgMinitial antibody after antigen exposure
primary immune response
5 Domains - 10 binding site
MC antibody in the spleen - 16IgGmost abundant antibody in body
responsible for 2/2 immune response
Crosses placenta - 17IgAfound in secretions
Peyer's patches in gut and breast milk
helps prevent microbial adherence and invasion in gut - 18IgDMembrane-bound receptor on B cells
an antigen receptor - 19IgEAllergic reactions
Parasite infections
Type I HS - 20Which immunoglobulins are opsonins?IgM and IgG
- 21Which immunoglobulins fix complement?IgM and IgG, requires 1 IgG or 1 IgM
- 22Which region on an antibody is for antigen regonition?variable region
- 23Which region on antibodies are recognized by PMNs, macrophages, and NK cellsConstant region
- 24Polyclonal Antibodiesmultiple binding sites to the antigen at multiple epitopes
- 25Monoclonal Antibodiesonly 1 binding site to the antigen at 1 epitope
- 26Type 1 Hypersensitivityimmediate hypersensitivity reaction
allergic reaction/anaphylaxis
IgE receptors on mast cells and basophils react with the antigen and cause release of histamine, serotonin and bradykinin - 27Examples of Type 1 HypersensitivityBee stings, peanuts, Hay Fever, Lymphazurin dye
- 28Symptoms associated with Type 1 Hypersensitivityurticaria, HoTN, bronchoconstriction, angioedema
- 29Treatment for Type 1 HypersensitivityEpinephrine and airway management
- 30Type 2 Hypersensitivity and examplesIgG or IgM reacts with cell bound antigen
ABO incompatibility, hyperacute rejection, myasthenia gravis - 31Type 3 Hypersensitivity and examplesImmune Complex deposition
Serum Sickness, SLE - 32Type 4 Hypersensitivity and symptomsDelayed-type Hypersensitivity
APCs present on Ag to Thelper, activated macrophages and destroy Ag
Takes 2-3Days
TB skin test (PPD) + contact dermatitis - 33Basophilsmajor source of histamine in blood
- 34Mast CellsMajor source of histamine in tissue, man cell type for type 1 HS
- 35Primary Lymphoid OrgansLiver, Bone, Thymus
- 36Secondary Lymphoid OrgansSpleen and Lymph Nodes
- 37Immunologic Chimera2 Different Cell Lines in one individual (ex BM transplants)
- 38IL-2converts lymphocytes to lymphokine-activated killer (LAK) and into tumor-infiltrating lymphocytes
- 39What to do for non-tetanus prone woundsGive tetanus toxoid only if patient has recieved <3 doses or tetanus status unknown, or >10years since booster
- 40What is a tetanus prone wound?>6hours old, obvious contamination and devitalized tissue; crush, burn, frostbite, missile injuries
- 41What to do for tetanus prone woundsalways give tetanus toxoid unless patient has had >/= 3 doses and it has been <5years since last booster
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- Surgery - Absite Review Flashcards on Immunology - Absite, created by Jennifer Huber on 30/05/2018.
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