Cephazolin

Description

Nursing SFE Nursing Flashcards on Cephazolin, created by Em J on 04/06/2018.
Em J
Flashcards by Em J, updated more than 1 year ago
Em J
Created by Em J over 6 years ago
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Resource summary

Question Answer
Trade names Kefzol - Cefazolin
Chemical name Cephazolin sodium
Therapeutic class anti-infective
Pharmaceutical class antibiotic - cephalosporin
Indications -Staphylococcal and streptococcal infections in people with mild-to-moderate penicillin allergy -Surgical prophylaxis -UTI
Action Bactericidal; interferes with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death.
Absorption Not well absorbed in GIT - given via IV for optimal absorption
Distribution Does cross placenta and into breastmilk - however is said to be safe
Metabolism & excretion Excreted unchanged in urine
Half-life 1.8 hours
contraindications/precautions -Some people who are allergic to penicillins are also allergic to cephalosporins -Those with heart failure or on sodium restriction - high levels of sodium -Immunocompromised individuals = high incidence of rash -Renal impairment
Adverse reactions Skin: rash GIT: diarrhoea, N + V, CNS: neurotoxicity at high doses/ renal impairment
Drug interactions May increase the effect of anticoagulants such as warfarin
Nursing assessment implications -Obtain specimen for culture -Baseline vital signs -Monitor person's response to administration
Education Tell patients to report adverse effects drink lots of fluids, and keep up nutrition
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