14046717
| Question | Answer |
| Trade names | Frusemide - Lasix - Uremide - Frusax |
| Indications | Oedema due to heart failure, renal impairment, liver cirrhosis or nephrotic syndrome |
| Action | Inhibits reabsorption of sodium & chloride in the ascending limb of the loop of henle |
| Therapeutic effect | Fast-acting, short duration diuresis |
| Absorption | 60% of oral dose in absorbed in GIT |
| Distribution | Easily crosses placenta and enters breastmilk |
| Metabolism & excretion | Metabolised in the liver and excreted through the kidneys (urine) |
| half-life | two hours |
| Contraindications & precautions | - pregnancy - gout - anuria - prostatic obstruction - dehydration - Allergy to sulphonamides |
| Adverse reactions | Can cause orthostatic hypotension, polyuria, dizziness, electrolyte imbalance & dehydration |
| Nursing assessment implications | - BP - FBC - Weight |
| Education | - Take in morning/ early afternoon at latest to avoid nocturia - take with food - Caution about dizziness when standing |
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