Flashcards

1: blood intro

Jumael Zafar BIOL 283 - Tranfusion science Uni English 8 cards

Cards in this deck (8)

1Blood facts - life span - respirati]on type- 120 days
- anaerobic
2RBC membraneMore than 50 transmembrane proteins of various abundance (~100 - 1,000,000/cell) are expressed in red blood cells
3Spectrin-actin-protein 4.1R junctional complex- α- and β-spectrin form an antiparallel heterodimer
- β-spectrin head binds ankyrin if
for membrane cohesion
- tail binds actin
- crucial for RBC deformation
4RBC life cycle 1. formation 2. circulation 3. death 4. globin fate 5. heme fate- Fe3+ + globin + vit B12 + erythropoietin
- for ~120 days
- in liver to heme & globin
- to aa and reused
- bilirubin /- poo/wee
5RBC antigens - most antigenic - medium antigenic - least antigenic- ABO & Hh (O gene is recessive)
- Rh
- Diego, MNS, kell, kidd, duffy
6The H antigen is the precursor for ABO antigens - H gene (chr19) - A allele (chr9) - B allele (chr9)- codes for fucosyltransferase which adds fucose to terminal gal
- codes for glycosyltransferase which adds N-acetylglucosamine to terminal gal
- codes for glycosyltransferase which adds D-gal to terminal gal
7Rh blood group- 49 different Rh antigens of which D, C, E, c and e are the most important
Two genes - RHD and RHCE (Chr1) - encode the Rh antigens
- If RhD gene present = Rh D+; if Rh D gene deleted = Rh D-
- Alternative splicing of RHCE gives rise to C, c, E or e proteins
8UniqueThe most common Rh haplotype in Caucasians, Asians, and Native Americans is DCe. In African populations, the Dce haplotype is slightly more common

Description: Uni BIOL 283 - Tranfusion science Flashcards on 1: blood intro, created by Jumael Zafar on 14/01/2020.
Created by: Jumael Zafar
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