2641370
Description
Flashcards by victoriascudamore, updated more than 1 year ago
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Created by victoriascudamore
almost 9 years ago
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| Question | Answer |
| Cetirizine | Anti-histamine- do not cross BBB (ionised at physiological pH) |
| Chlorphenamine | Antihistamine for anaphylaxis |
| Diazepam | Hypnotic - long life |
| Temazepam | Hypnotic - short life |
| Zopiclone | Z-hypnotic |
| Haloperidol | First generation anti-psychotic |
| Olanzapine/Risperidone | Second generation anti-psychotic associated with weight gain |
| Clozapine | Second generation anti-psychotic associated with agranulocytosis |
| Amitriptyline | Tri-cyclic antidepressant |
| Fluoxetine | SSRI |
| Citalopram | SSRI with the strongest affinity for 5-HT |
| Venlafaxine | SNRI |
| Mirtazepine | Atypical antidepressant |
| Cyclophosphamide | Alylating agent - cancer |
| Doxorubicin | Cancer drug- Anthracyclines - inhibit Topoisomerase II |
| Methotrexate | Inhibits DHFR enzyme (preventing folate metabolism) |
| Vincristine | Cancer drug- Binds to tubulin - preventing mitosis |
| Imatinib | Protein kinase inhibitor - cancer |
| Tamoxifen | Hormone antagonist of oestrogen - breast cancer |
| Cisplatin | Causes crosslinking of DNA - cancer |
| Darunavir | Protease inhibitor - HAART |
| Tenofovir | Nucleoside Reverse Trnscriptase Inhibitor |
| Efarvirenz | Directly inhibits reverse transcriptase by inhibition |
| Amoxicillin | Broad spectrum penicillin - first line against pnuemonia |
| Benzylpenicillin | Penicillin often given IV |
| Co-amoxiclav | Amoxicillin with B-lactamase |
| Piperacillin with Tazobactam | Penicillin with B-lactamase - first line against S. Aureus |
| Cefotaxime | First line treatment for meningitis |
| Meropenem | Used in severe sepsis - broad spectrum antibiotic |
| Vancomycin | Antibiotic reserved for MRSA |
| Trimethoprim | First line treatment in uncomplicated UTI |
| Chloramphenicol | Topical treatment for bacterial conjunctivitis |
| Clarithromycin | Hypersensitivity alternative for pnuemonia - macrolide |
| Erythromycin | Hypersensitivity alternative for tonsillitis - macrolide |
| Doxycycline | Compete with tRNA for binding site on ribisome - antibiotic |
| Gentamycin | Used in TB treatment - ototoxic |
| Clindamycin | Active against penciillin resistant staphylococci - binds to 50S ribosome |
| Ciprofloxacin | Inhibits bacterial DNA gyrase |
| Metronidazole | Active against obligate anaerobic bacteria - antabuse alcohol reaction |
| Nitrofurantoin | Used in UTI treatment (not Trimethoprim) |
| Rifampicin | TB treatment - binds to bacterial RNA polymerase |
| Ethambutol | Inhibit synthesis of mycolic acid - anti-TB |
| Pyrazinamide | Anti-TB drug with bactericidal activity |
| Quinine | Active against P. Falciparum - interrupts detoxification of Haemin |
| Chloroquine | Used in treatment of uncomplicated non-severe malaria |
| Artemisin Combination Therapy | Best treatment for P. Falciparum |
| Fluconazole | Inhibits synthesis of Ergosterol |
| Capsofungin | Active against B-1,3-glucan - component of fungal cell wall |
| Fluorocystine | Active against B-1,3-glucan - component of fungal cell wallI |
| Fluorocystine | Works on protein synthesis within the nucleus - anti fungal |
| Nystatin | Bind to ergosterol and create trans-membrane pores - leading to cell membrane collapse |
| Aspirin | Irreversibly acetylates COX-1 |
| Naproxen and Ibuprofen | Competitive COX-1 and COX-2 inhibitor |
| Celecoxib | Inhibitor of COX-2 with less side effects |
| Sumatriptan | Given in migraine attack - 5-HT antagonist |
| Morphine | Mu and Delta opiod agonist |
| Diamorphine | Very similar to morphine following deacetylation |
| Methadone | Used in opiod dependence |
| Codeine | Weak opiate |
| Tramadol | Oral opiate used in Chronic Pain |
| Lidocaine | Local Anaesthetic |
| Atropine | Prevents bradycardia and fluid secretion into respiratory tract - Anaesthetic adjunct |
| Isoflurane and Nitrous Oxide | Inhaled general anaesthetics |
| Propofol | Total general anaesthetic |
| Thiopental Sodium | IV General anaesthetic with very high lipid solubility |
| Bromocriptine | DA receptor agonist - parkinsons |
| Selegiline | MAO-B inhibitor |
| Donepezil | Long half life Acetylcholine esterase inhibitor used in Dementia treatment |
| Fludrocortisone | Synthetic analogue for Aldosterone - used in Addison's Disease |
| Rivastigmine | Short half life Acetylcholine esterase inhibitor used in Dementia |
| Phenytoin | Anti-epileptic targetting VGSCs with very high cerebellar toxicity associated with ataxia |
| Isoniazid | nhibits synthesis of mycolic acid [metabolised by NAT2] |
| Lamotrigine | Anti epileptic targetting VGSCs associated with Steven Johnson syndrome |
| Phenelzine | Monoamine Oxidase Inhibitor [Depression] |
| Carbamazepine | Anti-epileptic targetting VGSCs - also used in trigeminal neurlagia associated with agranulocytosis |
| Sildenafil | Phosphodiesterase 5 inhibitor - Erectile Dysfunction |
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