Flashcards
Vertebrate limb and eye development
Cards in this deck (31)
- 1Which T-box transcription factors are expressed for each limb?Wing - Tbx 5
Leg - Tbx4
(Tbx5 ----| Tbx4)
- 2T-box transcription factors drive the expression of _____FGFs
- 3What happens if an FGF-soaked bead is ectopically placed in an embryo?
- 4T-box transcription factors are induced by _______Retinoic acid
- 5Where does FGF-10 emanate from?C - Lateral plate mesoderm
- 6FGF-10 induces the ________Apical Ectodermal Ridge
- 7FGF-10 activates ____ which induces the AER ectoderm to release _____FGF-10 -> Wnt3a -> FGF-8
- 8Two models for proximo-distal patterningTIMING MODEL (specified depending on length of time spent in PZ)
SIGNAL MODEL (specified depending on signal received) - 9The zone of polarising activity secretes ______ from the _____ region of the limb budShh from the posterior region
- 10Three essential genes for D-V limb patterningLmx1
Wnt7a
Engrailed1
- 11Which genes are expressed dorsally and ventrally?Dorsal - Wnt7a
Ventral - Engrailed
- 12What happens when Lmx1 is knocked out?Ventralisation of feet
- 13Optic vesicles form from the ________________Diencephalon
- 14Optic vesicles induce the ______ ______________Lens placode
- 15What happens after the lens placode is induced?The optic vesicle and lens placodes invaginate
- 16Genes required for eye developmentPax6
Six3
Rx1 - 17Six3 and Rx1 control ___________Cell proliferation
- 18Once invaginated, the optic cup forms two walls. How is the outer wall formed?Cells produce melanin and become the pigmented retina
- 19Once invaginated, the optic cup forms two walls. How is the inner wall formed?Stem cells form progenitor cells which differentiate into the neural retina
- 20____ represses Pax6 at the midline forming a border to separate the visual fieldsShh
- 21In the neural retina, progenitor cells form 3 ____________ layersNeuroblastic layers
- 22Retinal progenitor cells migrate from the ______ Neuroblastic layer to form layersOuter NBL
- 23______ cells are formed last in the innermost NBLGanglion
- 24_______ cells are formed in the inner NBLBipolar
- 25Rods and cones are formed in the ______ NBLOuter NBL
- 26Loss of Shh signalling in eye development causes...?Holoprosencephaly
Cyclopia
No ventralisation of neural tube
Abnormal digits
- 27Baby rat eyes were stained with a ____ containing __________ to determine the lineage of neuroblastsStained with a virus containing B-galactosidase
- 28The lens is made up of transparent ___________ cellsCrystallin
- 29The lens placode becomes rounded and induces the overlying _____ to become the transparent ______Overlying ectoderm to become the cornea
- 30The cells in the lens undergo _________ and are continually replacedElongation
- 31Disease if lens stem cells no longer function and lens is not clearCataracts
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- Flashcards on Vertebrate limb and eye development, created by Nicola E Davies on 24/05/2015.
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- Nicola E Davies
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