2984837
| Question | Answer |
| What are the intrinsic coagulation factors? | Factors 8,9,11,12 |
| What are the extrinsic coagulation factors? | Factor 7 and tissue factor |
| What are the common pathway factors? | Factors 1,2,5,10...and 13 |
| What are the indications for FFP? | TTP/HUS, massive transfusion (to replete platelets and coagulation factors), PT/PTT >1.5 ULN with bleeding, warfarin reversal |
| What does PCC (prothrombin complex concentrate) contain? | Factors 2, 7, 9, 10, Proteins C and S |
| Name the factor Xa inhibitors | Rivoroxaban Fondaparinux Apixiban Edoxaban |
| Name the direct thrombin inhibitors | Dabigatran Bivalirudin Lepirudin Argatroban |
| What are the approved indications for rivaroxaban? | Non-valvular atrial fibrillation DVT/PE treatment DVT prophylaxis in patient undergoing knee/hip replacement surgery |
| Below which creatinine clearance can you not administer rivaroxaban? | Creatinine clearance <30 for DVT/PE For atrial fibrillation, don't give if creatinine clearance less than 15 |
| What are the PT and PTT like in a patient with factor 13 deficiency? | Normal (factor 13 is part of the common pathway) |
| What is fibrogammin? | Factor XIII |
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