Flashcards
Antineoplastic agents: Cytotoxic drugs
Cards in this deck (10)
- 1CyclophosphamideAlkylating agents
N7 Guanine
Nephrotoxic/Urotoxic - 2Platinum CompoundsAlkylating agents
N7 Guanine
-platin - 3MethotrexateAntimetabolite
จับ Dihydrofolate Reductase
Inhibit DNA Synthesis
+leucovolin (Antidote rescue) - 45-FluorouracilInhibit thiamine synthase
+leucovolin (Enhance) - 56-ThioguanineInhibit thiamine synthase
+leucovolin (Enhance) - 6DoxorubicinAntibiotics
จับ topoisomerase ไม่ให้คลายเกลียว
Cardiotoxicity - 7Vinca AlkaloidsMitotic Inhibitors
จับ B-tubulin
หยุด cell ช่วง M phase
Neurotoxicity - 8TaxanesMitotic Inhibitors
จับ B-tubulin
หยุด cell ช่วง M phase
Neurotoxicity - 9IrinotecanTopoisomerase Inhibitor
Topo I - 10EtoposideTopoisomerase Inhibitor
Topo II