Antineoplastic agents: Cytotoxic drugs

Champ
Flashcards by Champ, updated more than 1 year ago
Champ
Created by Champ about 6 years ago
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Cytotoxic drugs

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Question Answer
Cyclophosphamide Alkylating agents N7 Guanine Nephrotoxic/Urotoxic
Platinum Compounds Alkylating agents N7 Guanine -platin
Methotrexate Antimetabolite จับ Dihydrofolate Reductase Inhibit DNA Synthesis +leucovolin (Antidote rescue)
5-Fluorouracil Inhibit thiamine synthase +leucovolin (Enhance)
6-Thioguanine Inhibit thiamine synthase +leucovolin (Enhance)
Doxorubicin Antibiotics จับ topoisomerase ไม่ให้คลายเกลียว Cardiotoxicity
Vinca Alkaloids Mitotic Inhibitors จับ B-tubulin หยุด cell ช่วง M phase Neurotoxicity
Taxanes Mitotic Inhibitors จับ B-tubulin หยุด cell ช่วง M phase Neurotoxicity
Irinotecan Topoisomerase Inhibitor Topo I
Etoposide Topoisomerase Inhibitor Topo II
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