Flashcards
ERYTHROPOIESIS
Cards in this deck (18)
- 1What is erythropoiesis?RBC formation and production
- 2Ineffective erythropoiesisNo formation and no production
- 3ErythropoiesisRBC formation and production
- 4Ineffective erythropoiesisNo formation and no production
- 5differentiation RBC componentstem cell - progenitor cell - precursor cell - mature RBC
- 6Progenitor cell?BFU-E and CFU-E
- 7BFU AND CFUBFU
-depend on cytokine for proliferation and survival
-self renewal
CFU
-sensitive to EPO
- NO SELF RENEWAL
-generate hemoglobinized RBC (proerythroblast) - 8EPOHormone produced by kidney or fetal liver, in response to hypoxia
- 9Function of EPO-to regulate erythropoiesis
-for maturation of RBC - 10Factors of production of EPO-reduction in Hb concentration (anemia)
-reduced oxygen concentration (hypoxemia)
-decreased oxygen released from Hb (high oxygen affinity Hb)
-reduced oxygen delivery to kidney (vascular occlusion) - 11EPO receptorJanus Kinase molecule. Form dimer, phosphorylated CFU, increase erythropoiesis
- 12Mechanism of erythropoiesisActivation of EPO require synthesis of hypoxia inducible factor 1 which composed of alpha and beta subunit
- 13Hypoxic and normoxicHypoxic = both alpha and beta subunit are expressed, production of EPO
Normoxic = degradation of HIF-1-a by proteasome - no EPO produce - 14Kidney in erythropoiesis-sense O2
-produce EPO - 15Erythroid lineageAfter progenitor cell
Nucleo-cytoplasmic association (nucleus - cytoplasmic maturation) - 16Erythroid lineage- cellProerythroblast - basophilic - polychromatophilic - Orthochromatic - Reticulocyte - Erythrocyte
- 17Orthchromatic to reticulocyte undergo?Nucleus is extruded for deformability
- 18Erythropoiesis locationEmbryonic - yolk sac
6th week-6th month --- liver
6th month > all long bone cavity
adult - BM of axial skeleton
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- Medicine Flashcards on ERYTHROPOIESIS, created by Nisa Tyyrahhrahh on 20/06/2022.
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- Nisa Tyyrahhrahh
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