434905
Description
Flashcards by Sammy Crockett, updated more than 1 year ago
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Created by Sammy Crockett
over 10 years ago
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| Question | Answer |
| Microvascular | Nephropathy (Kidney) Retinopathy (Eye) Neuropathy (Nerves) |
| Non enzymatic protein glycation | Addition of glucose to protein Rate depends on ambient glucose conc Glycation can alter protein function/break down Results in Advance Glycation End products (AGEs) |
| Polyol pathway and retinopathy | Aldose reductase found in nerve cells and lens of eye Too much sorbitol damages the lens NADH depletion can lead to oxidative damage |
| Infections | Lots of sugar=more susceptible to infection Peripheral tissues most at risk due to narrow blood vessels Due to microangiopathy, ischemia, immunosuppression and hyperglycemia |
| Nephropathy | Due to glomerulosclerosis Hyaline nodules build up on walls of vessels |
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