Pharmacology-Test1-Study Set 1

jenniseegi
Flashcards by jenniseegi, updated more than 1 year ago
jenniseegi
Created by jenniseegi about 5 years ago
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This is the first set of pharmacology flashcards.

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Question Answer
ANTIBIOTIC-INHIBITORS OF CELL METABOLISM Sulfonamides, Trimethoprim
ANTIBIOTIC--CELL WALL INHIBITORS "Bring Down The Viscious Baracade" Beta lactams, Daptomycin, Telavancin, Vancomycin, Bacatracin
ANTIBIOTICS-PROTEIN SYNTHESIS INHIBITORS TETRACYCLINE (30S), MACROLIDES (50S), LINCOSAMIDE (50S) Clindamycin, LINEZOLID (50S)
BETA LACTAM NAMES Penicillins, Cephalosporins, Carbapenems, Monobactams, Beta Lactam inibitors pluse antibiotic combinations
HOW BETA LACTAMS WORK BACTERICIDAL: Inhibits TRANSPEPTIDASE, thus inhibits cell wall synthesis
PENICILLINS: MECHANISM OF ACTION 1. Enter via cell wall, 2. Bind to penicillin-binding protein, 3. Normal cell wall synthesis disrupted, 4. Bacterial cell wall lysis
AMINOPENICILLIN COVERAGE: HELPS H: Haemophilus influenza E: Escherichia coli L: Listeria monocytogenes P: Proteus mirabilis (UTI) S: Salmonella; Shingella
AMPICILLIN GOOD FOR Treatment of Shingella; Side effect: Rash
AMOXICILLIN GOOD FOR Treatment of Salmonella; Side effect: Rash
EXTENDED SPECTRUM PCN GOOD FOR Treatment of Pseudomonas( and Enterobacter; TCP: Takes care of Pseudomonas
PSEUDOMONAS Piperacillin (Zosyn)
ENTEROCOCCUS Ampicillin (Unasyn) IV/IM
NO PSEUDOMONAS COVERAGE Ampicillin (Unasyn) IV/IM
ZOSYN PIPERACILLIN + TAZOBACTAM; extended spectrum PCN
TIMENTIN TICARCILLIN + CLAVULANIC ACID; extended spectrum PCN
UNASYN AMPICILLIN + SULBACTAM; aminopenicillin
AUGMENTIN AMOXICILLIN + CLAVULANIC ACID; aminopenicillin
CEPHALOSPORINS Five generations, 1st treats more gram positive--> as generations pass, greater gram negative coverage
NO ENTEROCOCCUS COVERAGE Cephalosporins
CEPHALOSPORIN WITH MRSA COVERAGE Ceftaroline
CEPHALOSPORIN: MECHANISM OF ACTION BACTERICIDAL: Inhibit the synthesis of the cell wall
CEPHALOSPORINS GOOD FOR CSF PENETRATION 3rd Generation: Rocefin, Cefdinir, Ceftriaxone
CEPHALOSPORINS HAVE CROSS SENSITIVITY TO: Penicillin, 5-10% chance of cross reaction, common
1st GENERATION CEPHALOSPORINS CEFAZOLIN (Ancef)IV and p.o., alternative if PCN allergic, treats: surgical prophylaxis, URIs, otitis media CEPHALEXIN (Keflex)-p.o. only
DRUG OF CHOICE FOR SYPHILLIS PENICILLIN
THEOPHYLLINE Narrow therapeutic window, know how works
NEPHROTOXICITY VANCOMYCIN
SULFA A LOT OF WATER; BONE MARROW SUPPRESSION
FLUCONAZOLE PENETRATES BBB
AMPHOTERICIN B DRUG OF CHOICE FOR LIFE-THREATENING MYCOTIC INFECTIONS
FLUCONAZOLE DRUG OF CHOICE FOR CRYPTOCOCCAL MENINGITIS
TERBIFINE(LAMISIL) DRUG OF CHOICE FOR TREATING DERMATOPHYTES (onychomycoses)
TMP/SMX INHIBITS FOLIC ACID SYNTHESIS--> CELL DIVISION STOPPED
TMP/SMX (contraindications/warnings) DRINK WITH A LOT OF WATER, REDUCES BIRTH CONTROL EFFECTIVNESS, BONE MARROW SUPPRESSION, CNS PENETRATION
AMPHOTERICIN B MOA LIPOPHILIC BINDS TO ERGOSTEROL--> increased cell permeability
5-FLUCYTOSINE CONVERTED BY CYTOSINE DEAMINASE TO FLUOROURACIL-->thymidylate synthetase
FLUOROQUINOLONES GOOD BONE PENETRATION
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