4546968
Description
Flashcards by jenniseegi, updated more than 1 year ago
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Created by jenniseegi
about 8 years ago
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| Question | Answer |
| ANTIBIOTIC-INHIBITORS OF CELL METABOLISM | Sulfonamides, Trimethoprim |
| ANTIBIOTIC--CELL WALL INHIBITORS | "Bring Down The Viscious Baracade" Beta lactams, Daptomycin, Telavancin, Vancomycin, Bacatracin |
| ANTIBIOTICS-PROTEIN SYNTHESIS INHIBITORS | TETRACYCLINE (30S), MACROLIDES (50S), LINCOSAMIDE (50S) Clindamycin, LINEZOLID (50S) |
| BETA LACTAM NAMES | Penicillins, Cephalosporins, Carbapenems, Monobactams, Beta Lactam inibitors pluse antibiotic combinations |
| HOW BETA LACTAMS WORK | BACTERICIDAL: Inhibits TRANSPEPTIDASE, thus inhibits cell wall synthesis |
| PENICILLINS: MECHANISM OF ACTION | 1. Enter via cell wall, 2. Bind to penicillin-binding protein, 3. Normal cell wall synthesis disrupted, 4. Bacterial cell wall lysis |
| AMINOPENICILLIN COVERAGE: HELPS | H: Haemophilus influenza E: Escherichia coli L: Listeria monocytogenes P: Proteus mirabilis (UTI) S: Salmonella; Shingella |
| AMPICILLIN GOOD FOR | Treatment of Shingella; Side effect: Rash |
| AMOXICILLIN GOOD FOR | Treatment of Salmonella; Side effect: Rash |
| EXTENDED SPECTRUM PCN GOOD FOR | Treatment of Pseudomonas( and Enterobacter; TCP: Takes care of Pseudomonas |
| PSEUDOMONAS | Piperacillin (Zosyn) |
| ENTEROCOCCUS | Ampicillin (Unasyn) IV/IM |
| NO PSEUDOMONAS COVERAGE | Ampicillin (Unasyn) IV/IM |
| ZOSYN | PIPERACILLIN + TAZOBACTAM; extended spectrum PCN |
| TIMENTIN | TICARCILLIN + CLAVULANIC ACID; extended spectrum PCN |
| UNASYN | AMPICILLIN + SULBACTAM; aminopenicillin |
| AUGMENTIN | AMOXICILLIN + CLAVULANIC ACID; aminopenicillin |
| CEPHALOSPORINS | Five generations, 1st treats more gram positive--> as generations pass, greater gram negative coverage |
| NO ENTEROCOCCUS COVERAGE | Cephalosporins |
| CEPHALOSPORIN WITH MRSA COVERAGE | Ceftaroline |
| CEPHALOSPORIN: MECHANISM OF ACTION | BACTERICIDAL: Inhibit the synthesis of the cell wall |
| CEPHALOSPORINS GOOD FOR CSF PENETRATION | 3rd Generation: Rocefin, Cefdinir, Ceftriaxone |
| CEPHALOSPORINS HAVE CROSS SENSITIVITY TO: | Penicillin, 5-10% chance of cross reaction, common |
| 1st GENERATION CEPHALOSPORINS | CEFAZOLIN (Ancef)IV and p.o., alternative if PCN allergic, treats: surgical prophylaxis, URIs, otitis media CEPHALEXIN (Keflex)-p.o. only |
| DRUG OF CHOICE FOR SYPHILLIS | PENICILLIN |
| THEOPHYLLINE | Narrow therapeutic window, know how works |
| NEPHROTOXICITY | VANCOMYCIN |
| SULFA | A LOT OF WATER; BONE MARROW SUPPRESSION |
| FLUCONAZOLE | PENETRATES BBB |
| AMPHOTERICIN B | DRUG OF CHOICE FOR LIFE-THREATENING MYCOTIC INFECTIONS |
| FLUCONAZOLE | DRUG OF CHOICE FOR CRYPTOCOCCAL MENINGITIS |
| TERBIFINE(LAMISIL) | DRUG OF CHOICE FOR TREATING DERMATOPHYTES (onychomycoses) |
| TMP/SMX | INHIBITS FOLIC ACID SYNTHESIS--> CELL DIVISION STOPPED |
| TMP/SMX (contraindications/warnings) | DRINK WITH A LOT OF WATER, REDUCES BIRTH CONTROL EFFECTIVNESS, BONE MARROW SUPPRESSION, CNS PENETRATION |
| AMPHOTERICIN B MOA | LIPOPHILIC BINDS TO ERGOSTEROL--> increased cell permeability |
| 5-FLUCYTOSINE | CONVERTED BY CYTOSINE DEAMINASE TO FLUOROURACIL-->thymidylate synthetase |
| FLUOROQUINOLONES | GOOD BONE PENETRATION |
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