Flashcards
Dopamine Synthesis, Precursor Role and its Metabolism in the body by Tosin
Cards in this deck (24)
- 1Rate limiting step?Tyrosine hyroxylase converting Tyrosine to DOPA (Dihydroxyphenylalanine)
- 2Which substance inhibits Tyrosine Hydroxylase?a-methyl-para-tyrosine
- 3Meaning of Rate-limiting stepA critical step in a synthesis/metabolic pathway which determines the rate at which the following reactions go i.e. if its slow they are going to be slow also and vice versa
- 4Enzyme which converts DOPA to DopamineDOPA Decarboxylase (Aromatic amino acid decarboxylase)
- 5DOPA Decarboxylase can be inhibited by?MK-486
- 6Define a Catechol RingTwo hydroxyl groups on a benzene ring
- 7Dopamine converted to Noradrenaline by?Dopamine-B-hydroxylase
- 8All the enzymes require some sort of ____ for activity or for their reaction to proceedCofactor including metal ions
- 9Phenylethanolamine-N-methyltrasferase does what? It uses what compound for this?Converts Noradrenaline to Adrenaline using S-adenosylmethionine
- 10From action of Phenylethanolamine-N-methyltransferase, its ____is converted to ______.Cofactor, S-adenosyl-homocysteine
- 11Name the enzymes involved in each step (including the ones not in image)
- 12MAO stands for what?Monoamine Oxidase
- 13MAO pathway of metabolism involves...Converting Dopamine to an Aldehyde form, aldehyde dehydrogenase then converts this to DOPAC. Finally, COMT converts DOPAC to HVA
- 14What does DOPAC stand for?Dihydroxyphenyl acetic acid
- 15What does HVA stand for?Homovanillic acid
- 16Final Product of MAO Dopamine Metabolism PathwayHVA
- 17COMT stands for.....Catechol-O-methyltransferase
- 18COMT Metabolism pathway of Dopamine involves....Converting Dopamine to O-methyl dopamine. Then this is converted to aldehyde form by MAO. This form is changed to HVA by action of Aldehyde dehydrogenase
- 19Reserpine MOABlocks Vesicular Monoamine Transporter = dopamine and other monamines cannot be transported into vesicles for resynaptic release via exocytosis = less dopamine action
- 20Amphetamine MOAEnhances/Stimulates release of Dopamine from presynaptic vesicles
- 21Iproniazid MOAMAO inhibitor = prevent Dopamine metabolism = more dopamine available
- 22ImipraminePrevents re-uptake of Dopamine from synaptic cleft
- 23What is an autoreceptor?It is found on membranes of presynaptic nerve cells. It functions in a negative feedback loop i.e. stops further NT release. It is only sensitive neurotransmitters in which the nerve cell releases
- 24—
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- Description
- Synthesis of Dopamine and how its is a precursor for other catecholamine synthesis. Metabolism of dopamine also reviewed
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- Tosin O
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