Flashcards
Ig Classes
Cards in this deck (19)
- 1IsotypesIg classes based on 5 H chain variations
- 2L Chain VariationsKappa or Lambda (not both)
- 3Functional Changes In IsotypesDifferent Isotypes have different functions
- 4Different IsotypesHave different structures and bind to different receptors
- 5IgG (Most Common)- FunctionFixes compliment and promotes opsonisation
- 6IgG- Placenta CrossingOnly Ig to do so
- 7IgA SecretionDone by B cells (most common in external secretions)
- 8Serum IgAMonomer
- 9Secreted IgADimer
- 10IgA Secretion RequirementsIgA, and IgAR, a receptor found in the inner lining of epithelial cells
- 11IgA TranscytosisThe IgA and IgAR are passed through the epithelial cell
- 12IgA ExocytosisThe IgA and the IgAR remain bound (though it's partially degraded)
- 13IgECause activation of allergic response- recognised by Mast cells
- 14Role of IgMIncreases antigen avidity & is most effective at fixing compliemnt
- 15IgM StructureForms a pentamer held by disulphide bonds
- 16IgM & IgDForm the BCR
- 17AvidityOverall strength of Ig-Ag interaction
- 18B Cell RecognitionCan recognise any type of antigen (lipid/peptide/glycoprotein)
- 19T-Cell RecognitionOnly recognise small, processed peptides
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- Year 2 Flashcards on Ig Classes, created by gina_evans0312 on 01/03/2014.
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- gina_evans0312
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