Ig Classes

Flashcards by gina_evans0312, updated more than 1 year ago


Year 2 Flashcards on Ig Classes, created by gina_evans0312 on 03/01/2014.

Resource summary

Question Answer
Isotypes Ig classes based on 5 H chain variations
L Chain Variations Kappa or Lambda (not both)
Functional Changes In Isotypes Different Isotypes have different functions
Different Isotypes Have different structures and bind to different receptors
IgG (Most Common)- Function Fixes compliment and promotes opsonisation
IgG- Placenta Crossing Only Ig to do so
IgA Secretion Done by B cells (most common in external secretions)
Serum IgA Monomer
Secreted IgA Dimer
IgA Secretion Requirements IgA, and IgAR, a receptor found in the inner lining of epithelial cells
IgA Transcytosis The IgA and IgAR are passed through the epithelial cell
IgA Exocytosis The IgA and the IgAR remain bound (though it's partially degraded)
IgE Cause activation of allergic response- recognised by Mast cells
Role of IgM Increases antigen avidity & is most effective at fixing compliemnt
IgM Structure Forms a pentamer held by disulphide bonds
IgM & IgD Form the BCR
Avidity Overall strength of Ig-Ag interaction
B Cell Recognition Can recognise any type of antigen (lipid/peptide/glycoprotein)
T-Cell Recognition Only recognise small, processed peptides
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