Controlling T-Cell Activation

gina_evans0312
Flashcards by gina_evans0312, updated more than 1 year ago
gina_evans0312
Created by gina_evans0312 about 7 years ago
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Year 2 Flashcards on Controlling T-Cell Activation, created by gina_evans0312 on 03/13/2014.

Resource summary

Question Answer
Costimulation- Role Secondary signal required to prevent overstimulation of T-cells
Costimulation- Signal Binding of CD28 (on T-cells) and B7.1/7.2 on APC
Costimulation- Anergy Signal If antigen is presenting with Co-stimulation occurring, T-cell is permanently deactivated
Costimulation- Prevention of Autoimmunity Non Professional APCs don't have B7, so T-cells cannot be activated by normal, native cells
Inhibition of T-cells- CTLA-4 A CD28 homologue activated by CD28-B7 binding that competes with CD28 for B7
Inhibition of T-cells- CTLA-4 Affinity 20x higher than B7
Inhibition of T-cells- CTLA-4 Role Signals T cell to downregulate response
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