Aspirin

Andrew Street
Flashcards by Andrew Street, updated more than 1 year ago
Andrew Street
Created by Andrew Street almost 4 years ago
3
0

Description

Top 100 drugs.
Tags

Resource summary

Question Answer
Give indications for aspirin. • ACS & acute ischaemic stroke - to rapidly inhibit platelet aggregation & prevent or limit arterial thrombosis • Long term secondary prevention of thrombotic arterial events with CVS, cerebrovascular, & peripheral arterial DS • AF where warfarin & NOAC's are CI • Mild-to-moderate P & fever - NSAID's may be preferable
MOA of aspirin. Thrombotic events occur when platelet-rich thrombus forms in atheromatous arteries & occludes the circulation. Aspirin irreversibly inhibits cyclooxygenase (COX) to reduce production of the pro-aggregatory factor thromboxane from arachidonic acid, reducing platelet aggregation & the risk of arterial occlusion. The antiplatelet effect of aspirin occurs at low doses and lasts for the lifetime of a platelet (which does not have a nucleus to allow synthesis of new COX) and thus only wears off as new platelets are made.
SE's of aspirin. • GI irritation • GI ulceration & haemorrhage • Bronchospasm • Tinnitus - in high doses
CI's, cautions, & important interactions of aspirin. CI's: • <16 YO • Aspirin hypersensitivity • 3rd trimester of pregnancy Cautions: • Peptic ulcer (eg prescribe gastroprotection) • Gout Important interactions: Aspirin acts synergistically with other antiplatelet agents, which although therapeutically beneficial can lead to increased risk of bleeding. Thus, although it may be given with antiplatelet drugs (e.g. clopidogrel, dipyridamole) & anticoagulants (e.g. heparin, warfarin) in some situations (e.g. acute coronary syndrome), caution is required.
Show full summary Hide full summary

Similar

Adenosine
Andrew Street
Thrombus, embolism and stroke
Darren Reynolds
Acetylcysteine (N-acetylcysteine)
Andrew Street
GCSE AQA Biology 2 DNA & Cell Division
Lilac Potato
Using GoConqr to learn German
Sarah Egan
SFDC App Builder Quizlet (Dez version)
chris fernandez
mi mapa conceptual
Magda Hernandez
French Essay Writing Vocab
Gianna Chibesa
SISTEMAS NERVIOSO Y REPRODUCTIVO.
Diana Gonzales
Estructura de un Sistema Operativo
Oliver Axel Martinez Becerra
Gobierno de Ernesto Zedillo Ponce de León
Guillermo Romero