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Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| TNF-Alpha & IL6- Role | Proinflammatory cytokines that also confer insulin resistance |
| TNF-Alpha & IL6- Release | In the absence of inflammation |
| TNF-Alpha & IL6- Overexpression | In obesity, as there is more WAT, so more insulin resistance |
| TNF-Alpha & IL6- Method Of Action | P the serine residue of IRS1, so it cannot respond to Insulin receptor activation |
| TNF-Alpha & IL6- Inhibits | Insulin response & adiponectin |
| Resistin- Role In Humans | Unknown |
| Resistin- Role in Mice | Increased insulin resistance and decreased insulin stimulated glucose transport |
| Adiponectin- Role | Increased insulin sensitivity |
| Adiponectin- Release | Increased in weight loss, decreased in the obese/IL6/TNF-Alpha secretion |
| Adiponectin- Method of Action | Increased FA oxidation, decreased intracellular lipids and FA, decreased hepatic glucose poduction |
| Leptin- Role | Appetite suppressant, increases utilisation |
| Leptin- Release | Inc when fat stores are high, and vice versa |
| Leptin- Method of Action | Secretion of neuropeptide gamma |
| Leptin- Ineffective Gene Effects | Obesity and insulin resistance |
| Leptin- Overexpression | Insulin resistance |
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