769711
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Triggers | A variety of pathways ie. irradiation, lack of essential growth factors, CTLs... |
| Extracellular Pathway | Death Signal (i.e. Fas) binds to a receptor, beginning the caspase cascade |
| Intracellular Pathway | Cyt. C is released from the mitochondria, triggering the caspase cascade |
| Caspases (Caspase 8) | Upon activation, DED domain is cleaved and it can go activate Caspase 3 |
| Caspases (Caspase 3) | Does most of the work in causing apoptosis |
| BCL2 | Protects cells from apoptosis by preventing Cyt. C leakage |
| BAD | Binds to BCL2 and prevents this protection |
| BAX | Triggers Cyt.C leakage by puncturing the mitochondria |
| Cyt. C Leakage | Triggers APAF1 and Caspase 9 multimer formation, which triggers the caspase cascade |
| Other Proteins | Work to slow this process, so if it needs to be reversed, it can be |
| Recycling | All cellular proteins are recycled after apoptosis |
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