ANTIGEN PROCESSING and PRESENTATION

Flowchart nodes

• 1) Uptake of antigen by APC's: PATHOGEN, PAMP, TLR (depending on the pathogen)APC's = dendritic cells, B cells, and macrophages (PROFESSIONAL) MHC Class IIPhagocytes = All nucleated cells (MHC Class I) ex: viruses, anybody can get them! 

• 2) Particular APC depends on where the pathogen comes from:A) MHC Class I: intracellular B) MHC Class II: extracellular *Recognition of antigen (HLA + T cell Receptor) T cell response/activation depending on corresponding MHC Class molecule A) MHC Class I = CD8+ T cytotoxic (kill) B) MHC Class II = CD4+ T helper (mediate killing, alert other T cells, etc.)

• 5) Effector T cells encounter antigens and are activated Then Exert cellular function: T cell effector function 

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• 3) Cellular expansion and differentiation (into effector and memory cells)

• 4) Migration: interact with other cells and go to site of infection 

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