Flowchart
ANTIGEN PROCESSING and PRESENTATION
Flowchart content
1) Uptake of antigen by APC's: PATHOGEN, PAMP, TLR (depending on the pathogen)
APC's = dendritic cells, B cells, and macrophages (PROFESSIONAL) MHC Class II
Phagocytes = All nucleated cells (MHC Class I) ex: viruses, anybody can get them!
2) Particular APC depends on where the pathogen comes from:A) MHC Class I: intracellular B) MHC Class II: extracellular
*Recognition of antigen (HLA + T cell Receptor)
T cell response/activation depending on corresponding MHC Class molecule A) MHC Class I = CD8+ T cytotoxic (kill)
B) MHC Class II = CD4+ T helper (mediate killing, alert other T cells, etc.)
5) Effector T cells encounter antigens and are activated
Then Exert cellular function:
T cell effector function
3) Cellular expansion and differentiation (into effector and memory cells)
4) Migration: interact with other cells and go to site of infection
