STI's

STI's

SYPHILIS
1. Treponoma Pallidum
  1. Gram negative
  2. Axial filaments
2. Infection
  1. 1. Primary
    1. Chancre
    2. 4-6 wks
  2. 2. Secondary
    1. Fever
    2. Rash
    3. Liver infection
    4. Swollen lymph nodes
  3. 3.Tertiary
    1. Gumma
      1. Soft granular lesion
    2. Antibiotic resistance
      1. Immune complexes
        Inflammation
        Tissue destruction
  4. Congenital
    1. Skin lesions
    2. Deafness
    3. Bone malformation
3. Diagnosis
  1. Microscopy
  2. Serological testing
4. Treatment
  1. Chemotherapeutic
    1. Salvarsan
  2. Antibiotic
    1. Penicillin
5. Immune evasion
  1. Cell wall
6. X
Trends
1. Age
2. Geography
3. Sexual orientation
CHLAMYDIA
1. Chlamydia Trachomatis
  1. Diagnosis
    1. PCR
    2. Immunoassays
  2. Treatment
    1. Doxycycline
  3. Gram negative
  4. Small genome
2. 2 stage life cycle
  1. Reticulate body
    1. Replication
  2. Elementary body
    1. Infection
  3. Cell cycle
    1. 1.Attachment
      1. OmpA binds heparan sulphate
    2. 2.Entry
      1. T3SS injects TARP
        Induces uptake
    3. 3.Primary differentiation
      1. EB to RB
    4. 4.Cell division
      1. Rapid multiplication
    5. 5.Effector secretion
      1. CPAF
        Degrade host TF's
      2. Chronic inflammatory response
    6. 6.Secondary differentiation
      1. RB to EB (Intermediate form)
      2. Chromosomal condensation
      3. OMC formation
      4. T3SS formation
    7. 7.EB release
3. symptoms
GONORRHOEAE
1. Neisseria Gonorrhoeae
  1. Gram negative
2. Diagnosis
  1. Thayer Martin agar
    Annotations:
    - Vancomcin, inhibits gram positive Colistin, inhibits most gram neg
  2. PCR
3. Treatment
  1. 3rd gen cephalosporins
4. Virulence mechanisms
  1. Attachment pili
  2. Tight attachments
  3. Change surface proteins
    1. Recombination
      1. Transformation
      2. Gene exchange
    2. Antigenic variation
      1. Abberant recombination
    3. Sialylated lipopolysaccharide
      1. Resistant to complement and antibodies
      2. Mimics host cell surface
5. Symptoms
Anatomy of FRT

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