B5c - Running Repairs

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GCSE BIOLOGY Mind Map on B5c - Running Repairs, created by Chloe.Sharland on 15/06/2014.
Chloe.Sharland
Mind Map by Chloe.Sharland, updated more than 1 year ago
Chloe.Sharland
Created by Chloe.Sharland almost 11 years ago
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B5c - Running Repairs
  1. Heart conditions + diseases
    1. Hole in the heart
      1. The septum between the right and left sides of the heart isn't complete, blood can flow from one side to the other. This means that the blood going around the body will carry less oxygen, leading to tiredness + shortness of breath. Closed by surgery. Unborn babies get the oxygen they need from their mother + don't need working lungs. They don't need a double circulatory system, their heart has a hole between the right + left side. This closes soon after birth so that the double circulatory system can be established. When it fails to close, the baby has a ‘hole in the heart’.
      2. Heart valves
        1. The valves in the heart stop the blood flowing backwards. If the valves are damaged or weak, they cannot stop this backflow so well. The blood circulation is reduced, again leading to tiredness and shortness of breath. The faulty valves can be replaced by artificial valves.
        2. Blocked coronary arteries
          1. Fatty deposits build up in the walls of the coronary arteries, particularly smokers or diets high in saturated fats. These block the arteries, reducing flow of blood to the heart muscles. It can lead to a heart attack. By-pass surgery involves transplanting a vein from the leg to provide a route past the blockage.
          2. Different types of Surgery
            1. A heart transplant is a major operation and there is a shortage of suitable donors. The patient has to take drugs to suppress their immune system for the rest of their life - otherwise the new heart will be rejected by the body. Less difficult operations involve fitting a pacemaker or an artificial valve, and the body is unlikely to reject them. They may need to be replaced.
          3. Blood clotting
            1. Controlling clotting
              1. Sometimes clotting can happen abnormally inside the blood vessels, leading to heart attacks or strokes. The ability of the blood to clot can be reduced using anti-coagulant drugs such as: warfarin heparin aspirin
              2. It is important that blood is able to clot, otherwise a cut or similar injury could lead to dangerous blood loss. Blood contains tiny structures called platelets, and a protein called fibrin. When a blood vessel is damaged, a series of chemical reactions happen. Fibrin fibres form a mesh at the site of the wound and the platelets get stuck in this, forming a scab.
                1. Haemophillia
                  1. Haemophilia is an inherited disorder in which the blood does not clot easily. Its ability to clot is severely reduced because an essential clotting factor - a chemical within the blood - is partly or completely missing. This means that people bleed for longer than normal. People with haemophilia are treated with injections of the missing clotting factor, although there is no permanent way of increasing its level.
                2. Blood tranfusions
                  1. Blood groups
                    1. A B AB O
                      1. These are further subdivided into Rhesus positive and Rhesus negative (Rh+ and Rh–).
                      2. A blood transfusion may be needed in a medical emergency or during an operation. The blood used in the transfusion comes from stored donor blood. When a donor gives blood their blood group is determined and blood is collected from a vein. It is mixed with an anti-coagulant to stop it clotting, and stored in a fridge. When a patient requires a transfusion, their blood group is checked and matched with donor blood. The donor blood is warmed and put into the patient through a vein.
                      3. Agglutination
                        1. Antigens
                          1. Red blood cells carry antigens. These are substances that cause an immune response by the body and the production of antibodies. Antigen A and antigen B are two major blood group antigens
                          2. Agglutinins
                            1. Agglutinins are substances that can react with a particular antigen and cause agglutination or 'blood clumping'. Blood plasma may contain antibodies that can act as agglutinins with red blood cells. The table summarises which antibodies are present.
                            2. Blood groups and transfusions
                              1. A blood transfusion will fail if the recipient has antibodies that will agglutinate the red blood cells in the donated blood.
                                1. someone with blood group O can donate to anyone, because their red blood cells do not carry A or B antigens - they are 'universal donors'
                                  1. group AB patients can receive any type of blood, because they do not have anti-A or anti-B antibodies - they are 'universal recipients'
                                  2. It is important to match the blood group of the donated blood to the patient for a blood transfusion to be successful. Unsuccessful blood transfusions can lead to agglutination.
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