Regeneration

Ashley Elder
Mind Map by Ashley Elder, updated more than 1 year ago
Ashley Elder
Created by Ashley Elder almost 6 years ago
30
1

Description

Mind Map on Regeneration, created by Ashley Elder on 07/16/2014.

Resource summary

Regeneration
1 Stem-cell mediated

Annotations:

  • stem cells regrow tissue/organs
1.1 stem cells regrow tissue/organs
2 Epimorphosis

Annotations:

  • dedifferentiation--redifferentiation (new structure)
2.1 Salamander limb
2.1.1 amputated
2.1.1.1 plasma clot

Annotations:

  • 6-12 hours
2.1.1.1.1 wound epidermis
2.1.1.1.1.1 ECM degraded
2.1.1.1.1.1.1 cell dedifferentiation

Annotations:

  • bone cells cartilage cells fibroblasts myocytes
2.1.1.1.1.1.1.1 regeneration blastema

Annotations:

  • proliferate-- nAG -eventually redifferentiate-restricted progenetor cells-bone cells-cartilage cells-fibroblasts-myocytes
2.1.1.1.1.1.1.1.1 V-ATPase proton (H+) pump

Annotations:

  • no pump= no regeneration
2.1.1.1.1.2 apical epidermal cap (AEC)

Annotations:

  • wound epidermis thickens
2.1.1.1.1.2.1 Fgf8

Annotations:

  • secretes Fgf8 if nerves present
2.2 dedifferentiation
2.2.1 redifferentiation
3 Morphallaxis

Annotations:

  • -repatterning of existing tissue -little new growth
3.1 Hydra
3.1.1 basal disc (foot)
3.1.1.1 foot activation gradient
3.1.1.2 foot inibition gradient
3.1.1.3 shinguard

Annotations:

  • -just above basal disc -buds appear where Shinguard fades
3.1.2 hypostome (mouth/tentacles)
3.1.2.1 head activation gradient
3.1.2.1.1 peptides
3.1.2.1.1.1 head formation
3.1.2.1.1.1.1 Heady
3.1.2.1.1.1.2 Head
3.1.2.1.1.2 tentacles
3.1.2.1.1.2.1 Hym301
3.1.2.2 head inhibitor
3.1.2.3 "organizer"

Annotations:

  • -when transplanted can induce formation of 2nd axis -head actvation & inhibition signals -"self-differentiating" -inhibition signal inhibits formation of new organizing centers
3.1.2.3.1 Wnt

Annotations:

  • form head organizer
3.1.2.3.2 Goosecoid
3.1.2.3.3 Brachyury

Annotations:

  • head & body boundary
4 Compensatory regeneration

Annotations:

  • -differentiated cells divide -cell makes cell similar to itself - ie: mammalian liver
4.1 mammalian liver
4.2 differentiated cells divide
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