Respiratory Drugs

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Pharmacology 214.202 Massey university NZ
Samara Watts
Mind Map by Samara Watts, updated more than 1 year ago
Samara Watts
Created by Samara Watts almost 7 years ago
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Resource summary

Respiratory Drugs
  1. Bronchodilators
    1. B2 adrenergic agonists
      1. Short acting
        1. Salbutamol, terbutaline
          1. used for actue asthma
        2. Long acting
          1. eformoterol, salmeterol
            1. used as a symptom controller
          2. MOA: Stimulate B2 adrenergic receptors on the bronchial smooth muscles and stimulates sympathetic nervous system response - causing bronchodilation.
            1. Adverse effects: tremors, tachycardia, headache, increased blood glucose levels,
          3. Antimuscarinics
            1. Short acting
              1. Ipratropium
              2. Long acting
                1. tiotropium, glycopyrronium
                2. Theraputic action: bronchodilation, decreased mucous secretion action
                  1. MOA: block muscarinic receptors and inhibit the parasympathetic nervous system
                    1. Adverse reactions: dry mouth/throat irritation, blurred vision.
                3. Methylxanthines
                  1. Theophylline, aminophylline
                    1. Theraputic action: increased cellular activity and bronchodilation
                      1. MOA: inhibits the enzyme that degrades cAMP
                        1. Adverse reactions: insomnia, anxiety, tremors, tachycardia, nausea
                4. Preventer drug
                  1. Leukotriene receptor antagonists
                    1. Montelukast
                      1. Theraputic Action: mediate inflammatory reactions
                        1. MOA: blocks action of inflammation mediators
                          1. Adverse effects: headache, GI upset, thirst
                    2. Mast cell stabilisers
                      1. Sodium cromoglycale
                        1. Theraputic action: preventer group
                          1. MOA: prevents release of inflammatory mediators from mast cells
                            1. Adverse effects: Throat irritation, nausea
                      2. Steriods
                        1. Steroidal Anti-iinflammatory
                          1. Systemic corticosteriods
                            1. Prednisone, Methylprednisolone
                            2. Inhaled corticosteriods
                              1. Beclometasone, Fluticasone
                              2. Theraputic Action: bronchoconstriction and inflammation decreation
                                1. MOA: inhibits rupture of mast cells, decreases inflammatory mediators, suppresses antibody production and immune cells.
                                  1. Adverse reactions: Fluid and electrolyte imbalance, immunosuppressence
                              3. Combined formulations
                                1. Seretide & Symbicort
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