12207752
Description
Mind Map by Fatma Shwaylia, updated more than 1 year ago
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Created by Fatma Shwaylia
about 6 years ago
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A Lot of Fuss
- Anatomy and histology of the Duodenum
- C shaped round the head of pancreas. Start at pylorus of
stomach and end in jejunum L1, L2 and L3 Mostly peritoneal
and fixed except at gastroduodenal junction and
duodenojejunal junction
- Third
horizontal
- First Superior
- Second
descending
- Fourth
ascending
- Third
horizontal
- Duodenum has Brunner’s glands (mucous
glands)
- Ileum has Peyer’s
patches
- C shaped round the head of pancreas. Start at pylorus of
stomach and end in jejunum L1, L2 and L3 Mostly peritoneal
and fixed except at gastroduodenal junction and
duodenojejunal junction
- Malabsorption syndromes
- Intraluminal
- Pancreatic insufficiency
- Bile acid/salt deficiency
- Pancreatic insufficiency
- Brush border
and
transepithelial
transport
- Small bowel disease (celiac-
crohn’s- GVHD)
- Celiac disease
- Signs and symptoms of celiac disease
- , Vitamin K
deficiency, and
Excessive bruising
- Diarrhea
- Bloating, Gas
(flatulence, farting),
- Anemia,
Fatigue,
- bleeding. Abdominal
discomfort
- Failure to thrive in children
- the symptoms are not related to the bowel function, but instead are due to the consequences of
chronic malabsorption of vitamins and minerals.
- , Vitamin K
deficiency, and
Excessive bruising
- Immune-mediated damage of small bowel villi due to gluten exposure; associated with HLA-DQ2 and
DQ8
- Screening of the Celiac Disease
- a biopsy of the small intestine is the only way to diagnose celiac
disease.
- To confirm diagnosis
- CBC (anemia)
- ESR / CRP (inflammation)
- Comprehensive metabolic panel (determine
electrolyte, protein, and calcium levels, and to
verify the status of the kidney and liver )
- Vitamin D and B12 and folate to measure vitamin deficiencies.
- Iron, iron binding capacity or transferrin, and ferritin to detect iron deficiency
- Stool fat, to help evaluate malabsorption
- steatorrhea
- steatorrhea
- Stool fat, to help evaluate malabsorption
- Iron, iron binding capacity or transferrin, and ferritin to detect iron deficiency
- Vitamin D and B12 and folate to measure vitamin deficiencies.
- Comprehensive metabolic panel (determine
electrolyte, protein, and calcium levels, and to
verify the status of the kidney and liver )
- ESR / CRP (inflammation)
- CBC (anemia)
- physician should order a bone density test at time of
diagnosis to test for osteopenia/osteoporosis (thin bones)
- To confirm diagnosis
- Tissue Transglutaminase Antibodies (tTG-IgA)
- IgA Endomysial antibody (EMA)
- Total serum IgA
- Deaminated gliadin peptide (DGP IgA and IgG)
- Gluten Challenge
- Gluten Challenge
- Deaminated gliadin peptide (DGP IgA and IgG)
- Total serum IgA
- IgA Endomysial antibody (EMA)
- a biopsy of the small intestine is the only way to diagnose celiac
disease.
- Gluten is present in wheat and grains; its most pathogenic component is gliadin. l. Once absorbed,
gliadin is deamidated by tissue transglutaminase (tTG). 2. Deamidated gliadin is presented by antigen
presenting cells via MHC class II. 3. Helper T cells mediate tissue damage.
- Normal VS Celiac disease Histological Slide
- Screening of the Celiac Disease
- Treatment
- Lifelong Adherence to the Gluten-Free Diet
- Vitamins and Dietary Supplements
- , people with celiac disease are deficient in fiber, iron, calcium, magnesium, zinc, folate, niacin,
riboflavin, vitamin B12, and vitamin D, as well as in calories and protein. Deficiencies in copper and
vitamin B6 are also possible, but less common
- , people with celiac disease are deficient in fiber, iron, calcium, magnesium, zinc, folate, niacin,
riboflavin, vitamin B12, and vitamin D, as well as in calories and protein. Deficiencies in copper and
vitamin B6 are also possible, but less common
- Dermatitis herpetiformis -->Dapsone or sulfapyridine
- Lifelong Adherence to the Gluten-Free Diet
- Associated with
- Type 1 diabetes mellitus
- Autoimmune hepatitis
- Sjögren’s syndrome
- Multiple Sclerosis
- Addison disease
- Arthritis
- Idiopathic dilated cardiomyopathy
- Autoimmune thyroid disease
- IgA nephropathy
- Type 1 diabetes mellitus
- Complications
- Central and peripheral nervous system disorders
- Osteoporosis
- Lactose
intolerance
- Lymphoma and small
bowel cancer
- Iron deficiency anemia
- gall bladder malfunction
- Pancreatic insufficiency
- Central and peripheral nervous system disorders
- Signs and symptoms of celiac disease
- Celiac disease
- Disaccharidase
deficiency-
abetalipoproteinemia
- Infective enterocolitis
- Small bowel disease (celiac-
crohn’s- GVHD)
- Lymphatic transport TB- Lymphoma
–whipple’s disease
- chronic diarrhea, wt loss, flatulence, abdominal
distention& pain, anemia, muscle wasting
- Intraluminal
- Follow up
- Dietitian role
- Role of the Physician
- Assess symptoms
- Recommend a mental health
professional
- routine tests
- flu shot
- Repeat bone densitometry
- For adults, consider
repeat small intestinal
biopsy
- Assess symptoms
- Dietitian role
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