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12878723
Diabetic nephropathy
Description
Mind Map on Diabetic nephropathy, created by Nadeen Adi on 18/03/2018.
Mind Map by
Nadeen Adi
, updated more than 1 year ago
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Created by
Nadeen Adi
over 6 years ago
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Resource summary
Diabetic nephropathy
Anatomy of the kidney
Blood supply
Histology of the kidney
Physiology of glomerular filtration
Clearance
Volume of plasma cleared of the substance by the kidney in one minute
C ml/min (Clearance) = U x V / P
Glomerular filtration rate
the clearance of a substance freely filtered at the glomerulus but not reabsorbed or secreted in the tubules
Pathological features and types of glomerular diseases
Nephritic syndrome
Post streptococcal GN
Rapidly progressive GN (crescentic)
IgA nephropathy
SLE
Alport syndrome
Nephrotic syndrome
Primary
Secondary
SLE
Diabetes
Pathogenesis
1. High serum glucose levels lead to hyaline arteriolosclerosis in efferent arteriole
2. high GFR and microalbuminuria
3. progress to sclerosis of the mesangium of the glomerulus and nephrotic syndrome
Amyloidosis
Complications
hypertention
Acute kidney failure
Chronic kidney failure
Renal function tests
Serum Blood Urea Nitrogen (BUN) – 7-18 mg/dL
Serum Creatinine – 0.6-1.2 mg/dL
Serum BUN/Creatinine ratio - 15
Creatinine Clearance (CCr) – 97-137 mL/minute
Urinalysis
Treatment
Diuretics
Thiazide diuretics
Loop diuretics
Potassium sparing diuretics
carbonic anhydrase inhibitors
Osmotic diuretics
Kidney transplantation
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