African Trypanosomiasis

Amirul Aiman
Mind Map by Amirul Aiman, updated more than 1 year ago
5
1
0

Description

MBBS Tropical Medicine Mind Map on African Trypanosomiasis, created by Amirul Aiman on 07/04/2018.

Resource summary

African Trypanosomiasis
1 Summary
1.1 Sleeping sickness
1.2 T brucei group
1.2.1 Gambiense TbG
1.2.1.1 West + Central
1.2.1.2 Gradual
1.2.1.2.1 Human- Human
1.2.2 rhodesiense TbR
1.2.2.1 East + South
1.2.2.2 Rapid
1.2.2.2.1 Reservoir
1.2.2.2.1.1 Game
1.2.2.2.1.2 Cattle
1.3 Vector (transmission)
1.3.1 Tsetse fly
1.3.1.1 Painful bite
1.3.1.2 Rural woodlands + forest
1.3.2 Rarely
1.3.2.1 Bloodborne
1.3.2.2 Congenital
1.4 Locality
1.4.1 Sub Saharan
1.4.1.1 DR of Congo
1.4.1.2 South Sudan
1.4.1.3 Central African Rebuplic
1.5 Negelected Tropical Disease
1.6 misdiagnosis as psychosis after travel
2 Vector
2.1 Tsetse fly
2.1.1 warm+ Shaded
2.1.2 1-6 mo
2.1.3 Low infctn rate
2.1.3.1 2-3 per1000
3 Life cycle
3.1 1. Fly bite + injects parasite
3.1.1 2. Metacyclic trypomastigotes → BS trypomastigotes
3.1.1.1 3. Multiply via binary fission
3.1.1.1.1 4. Trypomastigotes in blood
3.1.1.1.1.1 5. Fly bite + ingest parasite
3.1.1.1.1.1.1 6. BS parasite→ procylic parasite@ tsetse fly midgut
3.1.1.1.1.1.1.1 multiply via binary fission
3.1.1.1.1.1.1.2 7. Procyclic parasite leave midgut→ epimastigotes
3.1.1.1.1.1.1.2.1 8. multiply @ salivary glands epi→ metacyclic
3.1.1.1.2 Human Stages
3.1.2 Tsetse fly Stages
4 Signs and Symptoms
4.1 Signs
4.1.1 Chancre
4.1.1.1 localised erythema
4.1.1.2 Indurated
4.1.1.3 Tender
4.1.1.4 Lymphadenopathy
4.1.1.4.1 trypanosome move to nearby nodes → lymphadenitis
4.1.1.4.2 painless
4.1.1.4.3 soft
4.1.1.4.4 mobile nodes
4.1.1.4.5 Common in TbG
4.1.1.4.6 @ posterior cervical "Winterbottom's Sign"
4.1.1.5 Onset in days
4.1.1.5.1 up to 3 weeks
4.1.1.6 Common in TbR
4.1.2 Hepatosplenomegaly
4.1.2.1 Anaemia
4.1.2.2 abnormal LFT
4.2 Symptoms
4.2.1 Parasitaemia
4.2.1.1 Myalgia
4.2.1.2 Fever
4.2.1.3 Headache
4.2.1.4 Weightloss
4.2.1.5 Rash
4.2.1.6 Itch
4.3 Complications
4.3.1 CVS
4.3.1.1 Myocardits
4.3.1.2 Effusions
4.3.2 Endocrince
4.3.2.1 Hypothyroidism
4.3.2.2 Hypoadrenalism
4.3.3 CNS
4.3.3.1 Psychosis
4.3.3.2 Convulsions
4.3.3.3 Insomnia/somnalence
4.3.3.4 Hyper/Para thenesia
4.3.3.5 Tremors/Ataxia/Focal signs
4.3.4 General
4.3.4.1 Wasting
4.3.4.2 Malnutrition
4.3.4.3 Infections
5 Dx
5.1 Demonstration of Parasite
5.1.1 Aspiration of chancre
5.1.2 Blood Film
5.1.2.1 blood concentration technique
5.1.2.2 Quantitative Buffy coat
5.1.2.2.1 QBC
5.1.3 Bone marrow
5.1.4 CSF
5.1.4.1 Mandatory
5.1.4.2 xclude CNS
5.1.4.3 Microscopy for trypanosomes
5.1.4.4 WCC > 5
5.1.4.5 Morula cells of Mott
5.1.4.5.1 Big Eosinophillic Plasma cell contain IgM
5.1.5 Serology
5.1.5.1 Population screening
5.1.5.2 CATT (Card Agglutination Test)
5.2 Ddx
5.2.1 HIV
5.2.1.1 Toxoplasmosis in HIV
5.2.1.1.1 CD<400
5.2.2 TB
5.2.3 Meningitis
5.2.4 Lymphoma
5.2.5 CNS vasculitis
5.2.6 Psychiatric illness
5.3 Prognosis
5.3.1 Fatal without Tx
6 Staging
6.1 Stage 1 (Early)
6.1.1 No CNS involvements
6.1.2 Haemolymphatics
6.2 Stage 2 (Late)
6.2.1 CNS involvements
7 Tx
7.1 TbG
7.1.1 S1- Pentamidine
7.1.2 S2 - Eflornithine / ±Nifurtimox
7.2 TbR
7.2.1 S1- Suramin
7.2.2 S2- Melarsoprol
7.3 Steroids often used
7.4 SE common
7.5 1-3 weeks
8 Control
8.1 Vector control
8.2 Population screening
8.3 Minimise contact
8.4 Prevention
8.4.1 aerial insecticide
8.4.2 Tsetse fly trap
8.4.3 insectiside impregnated screen
8.4.4 wild animal pop reduction
8.4.5 removal of woody vegetaion
Show full summary Hide full summary

Similar

GCSE Chemistry C1 - Carbon Chemistry ATOMS, MOLECULES AND COMPOUNDS (Easy)
Tess W
Biological molecules
sadiaali363
B2, C2, P2
George Moores
An Inspector calls - Gerald Croft
Rattan Bhorjee
GCSE AQA Physics - Unit 1
James Jolliffe
AS level Maths Equations to Remember
Gurdev Manchanda
Simple Present Tense (Test)
Onur Kalafat
Using GoConqr to teach science
Sarah Egan
New GCSE history content
Sarah Egan
FV modules 1-4 infinitives- ENTER ENGLISH
Pamela Dentler
Specific topic 7.7 Timber (tools/equipment/processes)
T Andrews