'The probability of occurrence of
some unwanted event or outcome'
Example calculation of risk: 19,429 UK
people died of an injury/poisoning in 2005.
Total population at the time was 60,209,408,
so we can calculate this as an average risk
19,429 in 60,209,408... OR 1 in 60,209,408÷19,429
--> =1 in 3099 --> =1÷3099 --> =0.00032 OR 0.032%
Factors that Increase the Risk
of Cardiovascular Disease
Lifestyle
DIET - high in saturated fat increases blood
cholesterol level, which increases atheroma
formation. High salt levels increase blood pressure
HIGH BLOOD PRESURE - increased
risk of damage to artery walls
Other causes include excessive alcohol consumption, stress and diet
SMOKING - carbon monoxide combines with HAEMOGLOBIN in
the blood, reducing the amount of oxygen being transported
NICOTINE makes platelets more
sticky so blot clots can form easily
Amount of ANTIOXIDANTS (help protect cells) in
the blood decreases - increased risk of CVD
INACTIVITY - lack of exercise
leads to high blood pressure
Beyond Our Control
GENETICS - some people inherit particular
alleles which make them more likely to have
high blood pressure or high cholesterol levels
AGE - increased age increases the risk of CVD
GENDER - men are at greater risk
High Blood Pressure (Hypertension)
Measure of the hydrostatic force of
the blood against blood vessel walls
A SPHYGMOMANOMETER measures blood
pressure - for a healthy average person the
reading should be 100-140mmHg for SYSTOLIC
pressure and 60-90mmHg for DIASTOLIC pressure
What determines
your blood pressure?
Contact between blood and vessel
walls causes FRICTION and effects the
flow of blood - PERIPHERAL RESISTANCE
ARTERIOLES and CAPILLARIES have
greater total SURFACE AREAS -->
more friction --> more resistance -->
slower blood flow --> lower pressure
If the walls of an artery/arteriole
contract, the vessel contracts,
increasing resistance
If they relax, the lumen is
dilated, so the resistance falls
OEDEMA - fluid building up in
tissues and causing swelling
At the arterial end of a capillary, blood is under pressure. This forces fluid
through the capillary walls into the intercellular spaces, forming TISSUE FLUID
The capillary walls prevent blood cells and larger
plasma proteins from passing through though
High blood pressure means more of the
fluid is forced out of the capillaries