B-Cell vs. T-Cell (General)

B-Cell vs. T-Cell

1. T-Cells

   • Migrate and mature in the thymus
     • Have Vertical Antigen Receptors
       • Bind to Antigen Fragments displayed by the MHC on the cell surface
         • Helper T- Cells
         • Cytotoxic T-Cells
         • Memory T-Cells

2. B-Cells

   • Lymphocytes that are part of Adaptive Immunity
     • Attack the same specific antigens, function differently
       • Each B- and T- Cell creates ~100,000 of antigen receptors of ONE TYPE
         • B- and T- Cells carrying the same specific antigen receptor proliferate in the presence of an infection
           • Antigen
             • Cell product (toxin-released into extracellular fluid)
             • Pathogenic cell itself - Proteins or polysaccharides
             • Epitope - accessible part
           • When binded to same antigen, proliferates and differentiates to:
             • Effector Cells (PRIMARY RESPONSE)
             • Memory Cells (SECONDARY RESPONSE)
   • Remain and mature in the bone-marrow
     • Have Y-Shaped Antigen Receptors
       • Share Constant Regions - anchors to cell surface
       • Bind to the epitope of the antigen - OUTSIDE cells
         • Plasma Cells
           • Secretes Antibodies
         • Memory B-Cells