Postreceptor Events

Ion Channel
1. Lies across membrane
2. Results from change in ion concentration within cell
3. Ex: acetylcholine and nicotinic receptor
G-Protein Activation
1. Guanine nucleotide-binding protein
2. Activation of G-protein on cytoplasmic side of membrane
  1. Open/close ion channel
  2. Stimulate second messenger
    1. cAMP
    2. calcium
    3. phosphoinositides
3. Ex: acetylcholine and muscarinic receptors
Tyrosine Kinase Stimulation
1. Phosphorylates macromolecules
2. Ex: insulin and peptide growth factors
Penetration of Cell Membrane
1. Drug must be very lipophilic to get through phospholipid bilayer
2. Drug interacts directly with intracellular receptors
3. Ex: steroids, sex hormones, thyroid hormones, statins

Resource summary

	Created by Shannon Grady over 10 years ago