17424973
Description
Mind Map by Zainab Kamal, updated more than 1 year ago
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Created by Zainab Kamal
about 5 years ago
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A 62-YEAR-OLD MALE
WITH SWELLING IN
NECK
- Rt.sided neck swelling
- noted it after sore throat & was prescribed antibiotics
- felt small swelling in Lt. inguinal region, dropped around 7-8kg
- cervical lymph node biopsy were ordered.
- sections show diffuse effacement of lymph node
architecture by large lymphoid cells
- diagnosis: Non-Hodgkin lymphoma
- confirmed the final diagnosis of Diffuse Large B cell NHL
- immunohistochemistry: +ve for CD19, CD20, and CD45 and -ve for
CD5, CD3. Variable expression of CD10 and BCL6 was noted.
- CT: Rt. cervical & Lt. inguinal with diffuse involvement
of retroperitoneal nodes, high LDH
- stage IIIB Diffuse large B cell Non-Hodgkin lymphoma.
- treated with six cycles of rituximab + CHOP chemotherapy
- R-CHOP
- R-CVP
- FCR
- DA-EPOCH
- R-CHOP
- low
- small lymphocytes, flollicular
- small lymphocytes, flollicular
- intermediate
- diffuse small, diffuse large, diffue mixed
- diffuse small, diffuse large, diffue mixed
- high
- large cell, immunoblastic, lymphoblastic
- large cell, immunoblastic, lymphoblastic
- miscellaneous
- treated with six cycles of rituximab + CHOP chemotherapy
- diagnosis
- biopsy
- Contrast CT
- X-ray
- PET
- CBC
- immunohistochemstry
- flow cytometry
- biopsy
- stage IIIB Diffuse large B cell Non-Hodgkin lymphoma.
- B cell lymphoma
- CD19, CD20
- CD19, CD20
- T cell lymphoma
- CD3, CD4, CD8
- CD3, CD4, CD8
- CT: Rt. cervical & Lt. inguinal with diffuse involvement
of retroperitoneal nodes, high LDH
- immunohistochemistry: +ve for CD19, CD20, and CD45 and -ve for
CD5, CD3. Variable expression of CD10 and BCL6 was noted.
- hodgkin
- reed stirnberg cells
- Ass. EBV
- localized, single
- reed stirnberg cells
- non hodgkin
- multiple, spread
- majority B cells
- Ass. HIV
- multiple, spread
- confirmed the final diagnosis of Diffuse Large B cell NHL
- diagnosis: Non-Hodgkin lymphoma
- Core needle biopsy
- Fine needle aspiration
- Excisional biopsy
- permits the hematopathologist to
evaluate the architecture of the lymph
node.
- permits the hematopathologist to
evaluate the architecture of the lymph
node.
- sections show diffuse effacement of lymph node
architecture by large lymphoid cells
- signs & symptoms
- swollen lymph nodes
- Abdominal pain
- Night sweats
- weight loss
- swollen lymph nodes
- cervical lymph node biopsy were ordered.
- risk factors
- low immunity
- infections
- HIV
- EBV
- H.pyori
- HCV
- HTLV-1
- HIV
- age above 60
- low immunity
- felt small swelling in Lt. inguinal region, dropped around 7-8kg
- lymph node distribution
- noted it after sore throat & was prescribed antibiotics
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