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17517435
gout
Description
Mind Map on gout, created by daliya ahmed on 30/03/2019.
Mind Map by
daliya ahmed
, updated more than 1 year ago
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Created by
daliya ahmed
about 5 years ago
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Resource summary
gout
Classification and staging
GoutChronic Disease- in 4 Stages (natural history)
Risk factors
Alcohol... Diet... Genetics... Gender... Age... Medications... Obesity... Medical
Alcohol and gout
inhibit uric acid secretion and increase urate production
Causes of Gout
Causes of Increased Source or Production
Causes of Increased Source or Production
Consumption
Anchovies, sardines, kidney, liver, and red-meat, fructose-sweetened drinks
Cell lysis & turnover
myeloproliferative & lymphoproliferative disorders
Genetic disorders:
HGPRT deficiency (Lesch-Nyhan syndrome) G6PD (von Gierke disease)
Causes of Decreased Elimination
Renal insufficiency or Medullary cystic KD
Thiazide diuretics, Niacin, Aspirin, Cyclosporine, Pembrolizumab
GLUT9 gene ↔ Solute Carrier 2A9 (SLC2A9) [↑ reabsorption of urate]
What about causes of Pseudogout?
Hyperparathyroidism Hemochromatosis Etidronate disodium therapy Angiography
Signs & symptoms
Podagra... Tophi... Swollen inflamed joint... Limited ROM
Complications of gout
Treatment
Acute gouty arthritis
NSAIDs Corticosteroids Colchicine
Hyperuricemia in gout
Allopurinol
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