gout

daliya ahmed
Mind Map by daliya ahmed, updated more than 1 year ago
daliya ahmed
Created by daliya ahmed over 2 years ago
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Description

Mind Map on gout, created by daliya ahmed on 03/30/2019.

Resource summary

gout
  1. Classification and staging
    1. Gout Chronic Disease- in 4 Stages (natural history)
      1. Risk factors
        1. Alcohol... Diet... Genetics... Gender... Age... Medications... Obesity... Medical
          1. Alcohol and gout
            1. inhibit uric acid secretion and increase urate production
        2. Causes of Gout
            1. Causes of Increased Source or Production
              1. Causes of Increased Source or Production
                1. Consumption
                  1. Anchovies, sardines, kidney, liver, and red-meat, fructose-sweetened drinks
                  2. Cell lysis & turnover
                    1. myeloproliferative & lymphoproliferative disorders
                    2. Genetic disorders:
                      1. HGPRT deficiency (Lesch-Nyhan syndrome) G6PD (von Gierke disease)
                    3. Causes of Decreased Elimination
                      1. Renal insufficiency or Medullary cystic KD
                        1. Thiazide diuretics, Niacin, Aspirin, Cyclosporine, Pembrolizumab
                          1. GLUT9 gene ↔ Solute Carrier 2A9 (SLC2A9) [↑ reabsorption of urate]
                2. What about causes of Pseudogout?
                  1. Hyperparathyroidism Hemochromatosis Etidronate disodium therapy Angiography
                  2. Signs & symptoms
                    1. Podagra... Tophi... Swollen inflamed joint... Limited ROM
                    2. Complications of gout
                      1. Treatment
                        1. Acute gouty arthritis
                          1. NSAIDs Corticosteroids Colchicine
                          2. Hyperuricemia in gout
                            1. Allopurinol
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