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Absolute insulin deficiency

Alyce D'souza English

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Absolute insulin deficiency

  1. No insulin production

    • Increased Counter regulatory horones
      • Proteolysis
        • amino acid production
      • Lipolysis
        • Creation of acety COA
          • Ketogensis
            • Increased B-Hydroxybutyrate
              • Increased acetone levels
                • acetone smeling breaths
            • METABOLIC ACIDOSIS
              • Respiratory compensation
                • Kussmauls Breathing
                  • decreased co2
                    • Decreased 02 to brain
                      • Ischaemia to brain
                  • DECREASED GCS
                    • Cerebral swelling
                      • Seizure
                    • DEHYDRATION
                      • osmotic diuresis
                        • polyuria
                        • Polydipsia
                        • Orthostatic hypotension
                          • Tachycardia
              • Decreased ph on ABG
              • abdominal pain, nausea and vomiting
        • decreased tryglycerides
          • Impart to free fatty acids
            • glycerol
            • ketones
  2. Stress, infection, reduced insulin production

    • Increased CRP & WCC
  3. Pancreatic beta cell defecit

    • reduced ATP
    • HYPERGLYCAEMIA
      • excretion of glucose & Ketones
        • Glomerular filtrate unable to absorb excess ketones
          • Glucosuria
            • Increased sodium excretion
              • Increased fluid loss
                • increased potassium and calcium excretion
                  • electrolyte imbalance
              • hyponatremia
      • Increased Osmolarity
        • Water and sodium move from ICF to ECF

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Mind Map on Absolute insulin deficiency, created by Alyce D'souza on 30/08/2019.
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Alyce D'souza
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