Salem doesn't remember

Salem doesn't remember

1. Anatomy of the Limbic system

2. Physiology of memory and learning

   • Intermediate long term memory
   • Short-term memory
   • Sensory memory
   • Long term memory

3. Acute delirium

   • serious disturbance in mental abilities
     • Causes
       • Certain medications or drug toxicity
       • Certain medical conditions (Stroke/ MI)
       • Metabolic imbalances
       • Chronic or terminal illness

4. Forgetfulness

   • Causes
     • Lack of sleep
     • Medications
     • Underactive thyroid
     • Alcohol
       • Alcohol messes with the hippocampus
       • Alcohol affects the short therm memory

5. Dementia

   • Development of memory impairment and other cognitive deficits severe enough to decrease the person’s capacity to function at the previous level.
     • Always related to injury of the CORTEX
     • Causes
       • Diabetes
       • Ethanol
       • Medication
       • Infection and sepsis
         • Slow Viruses
           • Characteristics example
             • Shivering
             • Dementia
             • Paralysis
             • Loss of muscle tone
           • caused by conventional viruses
             • -Prions -SSPE -AIDS -PML
     • Types

6. Alzheimer’s Disease

   • irreversible, progressive brain disorder that slowly destroys memory and thinking skills
     • Types
       • Mild Alzheimer’s
       • Moderate Alzheimer’s
       • Severe Alzheimer’s
     • Classification
       • Based on the Inflammatory Response
         • -Inflammatory -Non-Inflammatory -Cortical
       • Based on the Onset or Trigger Type
         • -Early-Onset Alzheimer's -Late-Onset Alzheimer's
     • Risk genes
       • APP
         • Contributes to disease when gets cleaved by the enzyme
       • PS-1
       • PS-2
       • APOE4
     • Signs and symptoms
       • Memory impairment
       • Difficulty concentrating, planning or problem-solving
       • Changes in mood
     • Pathophysiology
     • Investigations
       • Clinical criteria
       • MRI
       • Vascular pathology
       • EEG
       • Genetic testing
   • Management
     • Cholinesterase inhibitors
       • -Tacrine -Donepezil -Rivastigmine -Galantamine
     • NMDA antagonist
       • Memantine

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