Innate immunity Essay

Innate immunity Essay

1. Introduction

   • Discuss Healthy wound healing process Say what this assignment is reviewing ie, the role of the innate immune system to provide immediate response and prevent the spread of pathogens and its role in activating the adaptive immune system. 250 words
   • Main body
     • Define Innate immune system
       • definition ie collection of protective mechanisms. works rapidly, has no memory works to activate adaptive immune system
       • Goal to provide an inflammatory response in 3 stages
         • To bring Phagocytes (Macrophages, Dendritic cells, neutrophils,  monocytes and mast cells) to destroy, isolate and inactivate, remove debris and prepare for healing
         • stage 1 early response 0-4 hours
           • Leukocyte release (dentritic and B cells) Antimicobial peptide and proteins (AMP) Pattern recognition receptors (PRR)Mannose receptorsbacterial opposition by normal skin floraenzymes eg LysozymeOpsonisation
           • Stage 2 Intermediate response 4 -96 hours
             • Discuss Complement cascade PAMPS and DAMPS binding to PRR eg phagocytic cells, inflammatory cells, leucocytes and NKC. by DIAPEDESIS
             • Stage 3 Activation of adaptive immune system by Antgen presentation cells
               • Discuss wound closure as a result of a fully functioning immune system
                 • Importance to clinical practice;
                   • discuss the normal wound processes after Haemostasis of inflammation, proliferation and remodelling following successful activation of adaptive system. end goal: the wound will enter the proliferation phase and healthy pink granulation tissue will be seen within the wound bed.