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Ageing -Lecture 7

reesha.cornelio1 PATH30001 UNIVERSITY OF MELBOURNE English

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Ageing -Lecture 7

Underlying mechanism
- Stem cell base line population is decreased
  - Genetics
    - DNA DAMAGE
      - Ageing occurs due to the damage caused by DNA from the activation of ROS
    - REDUCED REPLICAITON
      - Overtime mutations such as the one in werners syndrome cause improper replicaiton causing cell loss
      - Also due to telemorease action compromise
    - PROTEIN DAMAGE
  - environment
    - NUTRIENT SENSING
      - IG-1 pathway contolling insulin receptors has shown to cause ageing
    - inflammation
      - IL-6 , IL8
      - NFKB
      - COMPLIMENT , NK CELLS
  - OTHER
    - Mscrophages
    - Autophagy
    - inflamageing
The effects of ageing
- Diabetes
- Osteoporosis
- infection suceptibility
- cancer
- neurodegeneration
- strke
- demina
- saropenia
- muscle degeneation
- vascullar di
Ageing is the deterioration associated with ageing of cell, organ of whole organism

Description: UNIVERSITY OF MELBOURNE PATH30001 (Ageing - Lecture 7 ) Mind Map on Ageing -Lecture 7, created by reesha.cornelio1 on 09/06/2015.
Created by: reesha.cornelio1
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