36356033
"Sana With Rash"
- PHYSIOLOGY OF COAGULATION
- DIFFERENCE BETWEEN PLATELETS AND
CLOTTING FACTORS DEFICIENCY
- DIFFERENCE BETWEEN PLATELETS AND
CLOTTING FACTORS DEFICIENCY
- TYPES OF BLEEDING
DISORDERS
- classified into problems with:
- Primary hemostasis
- formation of weak
platelet plug
- formation of weak
platelet plug
- Secondary hemostasis
- a strong fibrin clot through activation of
intrinsic/extrinsic/common pathways
- a strong fibrin clot through activation of
intrinsic/extrinsic/common pathways
- Vascular bleeding disorders
- Vitamin C deficiency, Septic vasculitis infections,
Henoch-Schonlein Purpura
- Vitamin C deficiency, Septic vasculitis infections,
Henoch-Schonlein Purpura
- Primary hemostasis
- INVESTIGATIONS OF
BLEEDING DISORDERS
- Primary Hemostasis
- Blood Count & Blood Film Examination.
- Bleeding Time (BT) & Platelet Function Assay (PFA)
- Blood Count & Blood Film Examination.
- Secondary Hemostasis
- Prothrombin Time (PT).
- Activated Partial Thromboplastin Time (aPPT)
- Thrombin Time (TT).
- Prothrombin Time (PT).
- Blood Count & Film Examination
- aPPT & PT
- Primary Hemostasis
- TREATMENT OF BLEEDING DISORDERS
- Hemophilia A
- If MILD give, DDAVP or
Arginine vasopressin
- If SEVERE give, recombinant factor 8 pre
operation and post for weeks
- If SEVERE give, recombinant factor 8 pre
operation and post for weeks
- If MILD give, DDAVP or
Arginine vasopressin
- Hemophilia B
- Recombinant factor 9
- Tranexamic acid For operations
- Tranexamic acid For operations
- Recombinant factor 9
- Liver disease
- Fresh frozen plasma
- Vitamin K
- Vitamin K
- Fresh frozen plasma
- Hemophilia A
- classified into problems with:
- WHAT IS IDIOPATHIC THROMBOCYTOPENIC
PURPURA?
- Thrombocytopenia is due to the destruction of platelets coated
by antibody
- ITP can lead to excessive bruising and bleeding internally, as well
as on and under the skin.
- Decreased platelet production by megakaryocytes in the bone marrow has
been discovered
- prognosis
- the condition isn’t serious or
life-threatening.
- acute ITP in children often resolves within 6
months or less without treatment.
- people can live for many decades with the
disease
- people can live for many decades with the
disease
- acute ITP in children often resolves within 6
months or less without treatment.
- the condition isn’t serious or
life-threatening.
- causes
- Autoimmune diseases
- certain medications
- pregnancy
- Autoimmune diseases
- CLINICAL PRESENTATION OF ITP
- Petechiae – pin prick rash
- Bruising
- Purpura – purple coloured spots on the skin
- Bleeding from the nose and gums
- Black blisters in the mouth
- Heavy menstrual periods
- Petechiae – pin prick rash
- TYPES OF ITP
- Acute ITP
- Chronic TP
- Acute ITP
- MANAGEMENT OF ITP
- Front line drug therapy:
- Corticosteroids
- IV Immunoglobin
- IV Immunoglobin
- Corticosteroids
- Second line drug therapy
- TPO receptor agonist
- Rituximab
- Rituximab
- TPO receptor agonist
- Splenectomy
- PREPARATION AND COMPLICATIONS OF
SPLENECTOMY
- Purpose
- Trauma
- Splenomegaly and Hypersplenism
- Splenomegaly and Hypersplenism
- Blood disorders
- Trauma
- Types
- Open approach
- Laparoscopic approach
- Open approach
- Preparation
- Complications
- Purpose
- PREPARATION AND COMPLICATIONS OF
SPLENECTOMY
- Front line drug therapy:
- EPIDEMIOLOGY
- ITP
- Acute ITP affect children
- Chronic ITP affect females ( 20-40 )
- Chronic ITP affect females ( 20-40 )
- Acute ITP affect children
- Bleeding disorders
- Hemophilia A > Hemophilia B > von
Willebrand disease
- Hemophilia A > Hemophilia B > von
Willebrand disease
- ITP
- Thrombocytopenia is due to the destruction of platelets coated
by antibody
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