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G Protein Coupled Receptors
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G Protein Coupled Receptors
aka Seven-Pass Transmembrane Receptor Proteins
Largest family of receptor proteins in mammals
- 30-50% drugs on market
- Human genome has many orphan GPCRs
Types of G alpha proteins
- Gs
- stimulates adenylate cyclase
- B Adrenergic Receptors
- Gi
- inhibits adenylate cyclase
- M2 Muscarinic ACh Receptor
- Gq
- stimulates phospholipase C
- M3 Muscarinic ACh Receptor
- Gy12/13
- altered conductance of G protein regulated K/ion channels
- Gs
GPCR Pathways
- Gi + M2 ACh receptor
- Decreased adenylate cyclase
- decreased cAMP
- decreased protein kinase A
- Decreased PKA mediated protein phosphorylation
- decreased protein kinase A
- decreased cAMP
- Decreased adenylate cyclase
- Gs + B Adrenergic receptor/norepinephrine
- Increased adenylate cyclase
- increased cAMP
- increased protein kinase A
- Increased PKA mediated protein phosphorylation
- increased protein kinase A
- increased cAMP
- Increased adenylate cyclase
- Gi + M2 ACh receptor
Information
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- Diploma/Certificado de qualificação profissional de nivel 3 Pharmacy Mind Map on G Protein Coupled Receptors, created by Connie Wang on 05/11/2015.
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- Connie Wang
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