sam.hilton
Mind Map by , created over 6 years ago

Mind Map on BOD 1, created by sam.hilton on 04/12/2013.

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sam.hilton
Created by sam.hilton over 6 years ago
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BOD 1
1 BOD
1.1 Endocrine disease
1.1.1 Infertility
1.1.1.1 Ovulatory dysfunction markers
1.1.1.2 Causes
1.1.1.2.1 Lifestyle
1.1.1.2.2 Infection
1.1.1.2.3 Ovulatory disorders
1.1.1.2.3.1 hyperprolactinemia
1.1.1.2.3.2 Androgen excess
1.1.1.2.3.2.1 CAH
1.1.1.2.3.3 Hormone imbalance
1.1.1.2.3.3.1 PCOS
1.1.1.2.3.4 Hypothalamic pituitary insufficiency
1.1.1.3 Maintenance of pregnancy
1.1.1.3.1 Common disorders
1.1.1.3.2 Common complications
1.2 Diabetes
1.2.1 Insulin
1.2.1.1 Effect on target tissues
1.2.2 IDDM
1.2.2.1 Pathophysiology
1.2.2.2 Clinical markers
1.2.3 NIDDM
1.2.3.1 Insulin signalling
1.2.3.1.1 Insulin receptor structure
1.2.3.1.2 TK-IRS-p110-pip2>pip3-PKB
1.2.3.1.2.1 PKB targets
1.2.3.1.2.1.1 GSK3
1.2.3.1.2.1.2 AS160
1.2.3.1.2.1.3 TSC1/2
1.2.3.1.2.1.4 FOXO
1.2.3.1.3 Signalling defects
1.2.3.1.3.1 IRS-1
1.2.3.1.3.2 aPKC
1.2.3.2 Pathophysiology
1.2.3.2.1 Effect of elevated glucose
1.2.3.2.1.1 AGE/RAGE system
1.2.3.2.1.1.1 Inflammation and mitochondria
1.2.3.2.2 Effect of elevated lipids
1.2.4 Complications
1.2.4.1 Nephropathy
1.2.4.2 Retinopathy
1.2.4.3 Neuropathy
1.2.4.4 Athesclerosis
1.2.5 Other types
1.2.5.1 MODY
1.2.5.1.1 11 types and mutations
1.2.5.1.2 Treatment
1.2.5.2 PNDM
1.2.6 Treatment
1.2.6.1 Diet/exercise
1.2.6.2 Drug therapy
1.2.6.2.1 Sulphonylureas
1.2.6.2.2 Glitazones
1.2.6.2.2.1 PPARY
1.2.6.2.3 Metformin
1.2.6.2.3.1 AMPK
1.2.6.2.4 DPP4 inhibitors
1.3 Hirschsprung's disease
1.3.1 Origin of ENS
1.3.2 Genetic ENS dysfunction
1.3.2.1 Transcription factors
1.3.2.1.1 SOX10
1.3.2.2 Ligands and receptors
1.3.2.2.1 Endothelin-3 pathway
1.3.2.2.2 Neurotrophin/RET pathway
1.3.2.3 Other candidate genes
1.3.2.3.1 Phox-2b
1.3.2.3.2 Ncx
1.3.3 Cell bio of crest migration
1.3.3.1 Imaging methods
1.3.3.2 Conclusion from avian work
1.3.4 Stem cell implants and restrictions
1.3.5 ICCs and C-kit
2 Cytoskeleton
2.1 Desmin
2.1.1 Role in muscle
2.1.1.1 Mitochodria
2.1.1.1.1 Myotubules
2.1.1.1.2 Plectin Isoforms
2.1.1.2 Role in Sarcolemma and Costamere
2.1.1.2.1 Functional role
2.1.2 Desmin related myopathy
2.1.2.1 Histological observations
2.1.2.1.1 Calcification
2.1.2.1.2 Fibrotic lesions
2.1.2.1.3 Mitochondrial dissorganisation
2.1.2.1.3.1 Number
2.1.2.1.3.2 morphology
2.1.2.1.3.3 Function
2.1.2.1.3.3.1 ADP induced respiration
2.1.2.2 Mutations
2.1.2.2.1 Phenotype
2.1.2.2.1.1 Protein aggregates
2.1.2.2.1.1.1 Pathogenesis
2.1.2.2.1.1.1.1 processed by casp 6
2.1.2.2.1.1.1.2 N termial product inhibits IF
2.1.2.2.1.1.1.3 Apoptosis
2.1.2.2.1.1.2 Treatment
2.1.2.2.1.1.2.1 anti-apoptotic factors
2.1.2.2.1.1.2.2 inc chaperone
2.1.2.2.1.1.2.3 inc autophagy
2.1.2.2.1.1.2.3.1 atg7
2.1.2.2.1.1.2.4 inc proteosome
2.1.2.2.1.1.2.4.1 pa28-alpha
2.1.2.2.1.2 Apoptosis
2.1.2.2.1.2.1 Anti-apoptotic factors Bcl-2
2.2 Proteastasis/myofribrillogenesis
2.2.1 The proteasome
2.2.1.1 Ubiquitination
2.2.1.1.1 Cardiac Calpain-1
2.2.2 Autophagy
2.2.2.1 Macro
2.2.2.2 Micro
2.2.2.3 CMA
2.2.2.3.1 Sarcomere specialised chaperones
2.2.2.3.1.1 Myosin
2.2.2.3.1.1.1 Hsp90/UNC-45
2.2.2.3.1.2 Desmin
2.2.2.3.1.2.1 aB-Crystalin
2.2.2.3.2 Roles
2.2.2.3.2.1 Quality control
2.2.2.3.2.2 Maintainence
2.2.2.3.2.3 AA source
2.2.2.4 Regulation
2.2.2.4.1 Growth factor
2.2.2.4.1.1 Atg genes
2.2.2.4.2 Energy
2.2.2.4.2.1 AMPK
2.2.2.4.3 Nutrient
2.2.2.4.3.1 eIF2alpha
2.2.3 Process

Annotations:

  • 1.Synthesised 2. Correctly folded 3. Assembled stoichiometrically (Hsp90) 4. Interact in a spatiotemporal manner
2.2.3.1 Dynamic remodelling
2.2.3.1.1 Mechanical
2.2.3.1.2 Metabolic

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