PDH

PDH

1. PDH Phosphatase Activates PDH

   • PDH (Inactive)
     • Phosphorylated
   • To Activate PDH Phosphatase
     • Increased Mg2+ & Ca2+, available from muscular contraction

2. PDH Kinase Deactivates PDH

   • To Deactivate PDH kinase
     • Increased levels of pyruvate, NAD+, CoASH, ADP and Ca2+
       • CA2+ from muscle contraction
       • During exercise pyruvate increases due to enhanced glycolysis = PDH activated. ADP increases due to ATP hydrolysis
   • To activate PDH Kinase
     • Increased levels of ATP, NADH and Acetyl CoA
       • When glycolysis and beta-oxidation occur rapidly result in build up of acetyl CoA.
   • PDH (Inactive)

3. Dephosphorylated

4. Forms acetyl CoA from Pyruvate

5. Regulates CHO and Lipid oxidation