Dopamine Pathways in the brain by Tosin

Tosin O
Mind Map by Tosin O, updated more than 1 year ago
Tosin O
Created by Tosin O about 4 years ago
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Description

All four Pathways Dopamine is involved in

Resource summary

Dopamine Pathways in the brain by Tosin
1 Mesolimbic
1.1 Physiology: Projections from VTA (A10) to N. Ac (the Olf Bulb and Amgydala also)
1.1.1 Motivation, Emotion, REWARD!

Annotations:

  • Regulates these behaviours
1.1.1.1 Overactivity = Positive Symptoms of Szh

Annotations:

  • These include Delusions, Hallucinations and Thought Disorder and other Psychosis (reality testing is impaired) Furthermore = Catatonia (immobility/ non-purposeful movement)
1.2 D2 Antagonism Here = Alleviate Positive symptoms in Szh

Annotations:

  • Underactivity of this results = Antipsychotic Drug MOA
2 Mesocortical
2.1 Physiology: Projections from VTA (A10) to Prefrontal Cortex (PFC)
2.1.1 Dorsal Lateral PFC = Cognitive Functions
2.1.1.1 Cognitive Deficits in Szh
2.1.2 Ventral Lateral PFC = Emotions and Affect
2.1.2.1 Overactivity = Negative Symptoms of Szh
2.2 D2 Antagonism here = Alleviate Szh Symptoms
3 Nigrostriatal Pathway
3.1 Physiology = Projections from Substantia Nigra (A9) to Striatum (caudaute nuclues and putamen)
3.1.1 Controls Movement indirectly - Overactivity = Tardive Dyskinesia & Underactivity = Parkinsonism

Annotations:

  • See Basal Ganglia Pathways! Involved in preventing non-purposeful movement
  • Parkinsonism = Movement disorder & clinical syndrome caused by lesions/damage to Basal ganglis'a Substantia Nigra
3.2 D2 Block = Antipsychotic use side affects

Annotations:

  • In particular the Extrapyramidal side effects = movement disorders
  • These disorders involve involuntary movements 
4 Tuberoinfundibular
4.1 Physiology = Projections from Hypothalamus (arcuate and periventricular nuclei) to infundibular region in medial eminence

Annotations:

  • From one part of the hypothalamus to the other
  • Portal circulation between Medial eminence and Anterior pituitary = Dopamine released here
  • Dopamine inhibits Prolactin release
4.1.1 Hyperactivity = Too little Prolactin
4.1.2 Underactivity = Too much Prolactin

Annotations:

  • So D2 Blockade = Hyperprolactineamia
  • This is another side effect of Antipsychotic Drugs
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