Jodie Evans
Mind Map by Jodie Evans, updated more than 1 year ago


Mindmap on Monoclonal Antibodies as they relate to the treatment of breast cancer and RA

Resource summary

1.1 Chronic Inflammatory Disease
1.1.1 Remicade (Infliximab) Pharmacological Class & Indications Class Biologic Agents Indications Tumor necrosis factor (TNF) inhibitors Main Disease State Rheumatoid Arthritis Physiological Concepts Autoimmune disease where the immune system attacks the joints. Joint pain, tenderness, swelling and stiffness for 6 weeks or longer, morning stiffness for 30 minutes or longer, more than 1 joint is affected, the same joints on both sides of the body are affected, fatigue, loss of appetite, and a low-grade fever Non-Drug Treatments/Lifestyles Modifications Heat & cold therapies, Orthotics & splints, Therapeutic exercise, Healthy eating with an anti-inflammatory diet and plenty of rest Ongoing Monitoring Periodic labs for Serum C-reactive protein levels, X-rays for progression or remission of disease activity, Reduction of signs & symptoms, TB testing prior to & during treatment and Monitor for skin cancer Alternative Disease States Crohn's Disease, Psoriasis, Ankylosing Spondylitis, Psoriatic Arthritis Routes of Administration & Appropriate Populations Adults & Geriatrics Dosed using body surface area (BSA) or weight-based so doses can vary Pediatric & Juvenile - orphan drug designation IV Only. Must be infused using 0.9% NS. Not compatible with dextrose Drug & Food Interactions Drug Drug Interactions Anakinra, Tacrolimus, Cyclosporine, Tocilizumab, Paclitaxel, Abatacept, Sirolimus, Warfarin, Quinidine, Rilonacept, Phenytoin, Live Vaccines Food Interactions NONE Black Box Warnings & Adverse Effects Black Box Warnings Increased risk for serious infections including TP, sepsis & fungal infections Lymphoma & possible other malignancies in children & juveniles Adverse Effects Acute Coronary Syndrome, Cardiorespiratory Arrest, Chest Pain, Heart Failure, Hypertension, Hypotension, Myocarditis, Peripheral Edema, Systemic Vasculitis
1.2.1 Herceptin (Trastuzumab) Main Disease State Breast Cancer Physiological Concepts Breast lump, Abnormal mammograms, Visual or feel changes in the breast, Blood-stained or clear fluid discharge from nipple Non-Drug Treatments/Lifestyle Modifications Seek emotional support, Eat healthy, Reduce stress, Limit or eliminate alcohol consumption, Exercise regularly, Maintain healthy weight Ongoing Monitoring During Treatment: Labs & Cardiac assessments; Post Treatment: Regular health screening, Vitamin D levels checked regularly & Continue mammograms Alternative Disease States Gastric Cancer, Stomach Cancer & Pancreatic Cancer (Off label/Orphan) Pharmacological Class & Indications Class Biologic Agents Indications Human epidermal growth factor receptor (HER2) inhibitor Drug & Food Interactions Drug Drug Interactions Warfarin, Dexamethasone, Tamoxifen, Vitamin D3 & Zofran Food Interactions Grapefruit Routes of Administration & Appropriate Populations IV Only. Must be infused using 0.9% NS. Not compatible with dextrose. Adults & Geriatric Only Dosed using body surface area (BSA) or weight-based so doses can vary Black Box Warnings & Adverse Effects Black Box Warnings Cardiomyopathy - more common when used in conjunction with other cytotoxic agents Fatal Infusion Reactions & Pulmonary Toxicity - usually seen within 24 hours of infusion Embryo-Fetal Toxicity - Should not be used during pregnancy Adverse Effects Heart Failure, Edema, Tachycardia, Rash, Abdominal Pain, Diarrhea, Loss of Appetite, Nausea, Vomiting, Anemia, Backache, Headache, Dizziness, Insomnia, Cough, Neutropenia, Thrombosis
2.1 Additional MABS
2.1.1 Avastin/Bevacizumab Rituxan/Rituximab Stelara/Ustekinumab Adcetris/Brentuximab Erbitux/Cetuximab Yervoy/Ipilimumab Vectibix/Panitumumab Cyramza/Ramucirumab Humira/Adalimumab Cimzia/Certolizumab pegol Simponi/Golimumab Opdivio/Nivolumab Vectibix/Panitumumab Keytruda/Pembrolizumab Actemra/Tocilizumab Kadcyla/Ado-Trastuzumab Emtansine
Show full summary Hide full summary


Drug absorption, distribution, metabolism and excretion
Hannah Tribe
Exam 1 Medications
Justin Veazey
Monoamine pharmacology -Antidepressant drugs - Dr. Emma Robinson
Anna mph
Jamie R Pascual
General Anaesthetics Part 1 - Steve Fitzjohn
Anna mph
Cognition and Dementia - Alzheimer's disease.
Anna mph
Local Anaesthetics
Anna mph
Mark George
Drug Abuse and Drug Addiction - L1
Anna mph
G- Couple Protein Receptors
Has Maj