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Transplantation

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Mind Map on Transplantation, created by sam.hilton on 01/05/2013.
sam.hilton
Mind Map by sam.hilton, updated more than 1 year ago
sam.hilton
Created by sam.hilton about 11 years ago
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Resource summary

Transplantation
  1. Transplantable tissues
    1. Skin
      1. Kidnney
        1. Liver
          1. Heart
            1. Lung
              1. Pancreas
                1. Cornea
                  1. Bone Marrow
                    1. Face
                    2. Types
                      1. Autograft
                        1. Allograft
                          1. Isograft
                            1. Xenograft
                              1. Problems
                                1. Antibodies
                                  1. Hyperacute rejection
                                    1. Alpha1-3Gal
                                      1. transgenic pigs?
                                  2. Complement
                                    1. PERVS
                                2. Matching
                                  1. MHC
                                    1. MLR
                                      1. ABO
                                      2. Graft rejection
                                        1. Types
                                          1. Hyperacute
                                            1. ABO missmatch
                                              1. Pre existing antibodies
                                            2. Acute
                                              1. MHC missmatch
                                              2. Chronic
                                              3. T cell response
                                                1. Direct/indirect allorecognition
                                                2. Minor H antigens
                                                  1. MHC I
                                                    1. Polymorphic self proteins
                                                  2. GVHD
                                                    1. Immunosuppresive drugs
                                                      1. Cyclosporin A
                                                        2. Tacrolimus
                                                          1. Blocks calcineurin
                                                            1. dephosphorylation of NF-AT blocked
                                                              1. IL-2 blocked
                                                          2. Sirolimus
                                                            1. Binds mTOR
                                                              1. Prevents cell cycle in t cells
                                                            2. Side effects
                                                              1. Other drugs
                                                                1. Prednisone
                                                                  1. Azathioprine
                                                                    1. Anti-CD3 antibodies
                                                                      1. siRNA
                                                                        1. Tregs
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