Transplantation

sam.hilton
Mind Map by sam.hilton, updated more than 1 year ago
sam.hilton
Created by sam.hilton about 7 years ago
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Mind Map on Transplantation, created by sam.hilton on 05/01/2013.

Resource summary

Transplantation
1 Transplantable tissues
1.1 Skin
1.2 Kidnney
1.3 Liver
1.4 Heart
1.5 Lung
1.6 Pancreas
1.7 Cornea
1.8 Bone Marrow
1.9 Face
2 Types
2.1 Autograft
2.2 Allograft
2.3 Isograft
2.4 Xenograft
2.4.1 Problems
2.4.1.1 Antibodies
2.4.1.1.1 Hyperacute rejection
2.4.1.1.1.1 Alpha1-3Gal
2.4.1.1.1.1.1 transgenic pigs?
2.4.1.2 Complement
2.4.1.3 PERVS
3 Matching
3.1 MHC
3.2 MLR
3.3 ABO
4 Graft rejection
4.1 Types
4.1.1 Hyperacute
4.1.1.1 ABO missmatch
4.1.1.1.1 Pre existing antibodies
4.1.2 Acute
4.1.2.1 MHC missmatch
4.1.3 Chronic
4.2 T cell response
4.2.1 Direct/indirect allorecognition
4.3 Minor H antigens
4.3.1 MHC I
4.3.1.1 Polymorphic self proteins
4.4 GVHD
4.5 Immunosuppresive drugs
4.5.1 Cyclosporin A
4.5.1.1
4.5.2 Tacrolimus
4.5.2.1 Blocks calcineurin
4.5.2.1.1 dephosphorylation of NF-AT blocked
4.5.2.1.1.1 IL-2 blocked
4.5.3 Sirolimus
4.5.3.1 Binds mTOR
4.5.3.1.1 Prevents cell cycle in t cells
4.5.4 Side effects
4.5.5 Other drugs
4.5.5.1 Prednisone
4.5.5.2 Azathioprine
4.5.5.3 Anti-CD3 antibodies
4.5.5.4 siRNA
4.5.5.5 Tregs
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