22.214.171.124.1 UVR-Vita D synthesis-Th1 have Vita D receptors
126.96.36.199.1.1 activation of these receptors reduces immune activity INVITRO
188.8.131.52.2.1 cytokine signaling & other mech. does not involve VitaD
6 MS genetics
6.1 Risk .02% of pop.
7 Potential triggers
7.1 infectious agent
7.2 genetic predisposition
7.3 environmental factors
8 An MS "Attack"
8.1 change in neurological function more than 24 hrs
8.2 episode last avg. 3-6 wks
8.2.1 length of episode decreased w/ steroid treatment
8.3 Not MS attack
8.3.1 change neurolog. due to infection/fever
most common infections are UTIs/URIs
-experience uhthoff's phenomenon-which is recurrence/worsening of prior MS symptoms secondary to elevation in for body temp.
Mechanism: chronic demyelination W transient slowing of conduction
9 How is MS diagnosed?
9.1 Dissemination in Space & Time
diagnostic criteria for MS
9.1.1 T2 lesions in at least 2 of 4 areas of CNS
184.108.40.206.1 "classic"periventricular shape
220.127.116.11.2 ovoid or dawsons finger
18.104.22.168.3 rep-inflammation around medullary veins (outward ventricles