PAH-Neuroendocrine Response To Exercise

PAH-Neuroendocrine Response To Exercise

1. Made up of the:

   • Nervous System, Para and symp working in opposing ways
   • Endocrine System, Secretion of hormones
     • Hormones look for certain cells (target cells who have the right receptors)
   • Nerv Sys may stim Endo sys to secrete certain hormones

2. Differences between the two systems

   • Nervous System
     • Wired System
     • Neurotransmitters released diffuse over short distance
     • Rapid Response
     • Co-ordinates rapid+precise response
   • Endocrine System
     • Wireless
     • Hormones travel a long distance
     • Slow+long lasting response
     • Controls long duration actions

3. Types of Hormones

   • LIPID SOLUBLE: Bound to transporter proteins, eg Testosterone, estrogen, thyroid, calcitrol, progesterone
   • STEROID: Lipid soluble, Testosterone, estrogen etc
   • AMINO ACID DERIVATIVES: Non lipid soluble, seratonin, melatonin
   • POLYPEPTIDES: Non lipid soluble, growth hormone, TSH
   • EICOSANOIDS: Derived from arachidonic acid, leukotrines, prostaglandis
   • Roles of Hormones
     • ENDOCRINE: Dist in blood, binding to local target cells
     • PARACRINE ACTION: Acts locally, diffusing into neighbouring cells
     • AUTOCRINE ACTION: Acts on the cell that produced it to have an effect

4. Effect of Ex

   • RESISTANCE: Largest hormonal elevations, involving hormones like growth H and Test
     • Increase of hormones means more receptors are likely to bind to H properly, triggering a larger response