8599716
Description
Mind Map by Celeste Jacobs, updated more than 1 year ago
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Created by Celeste Jacobs
about 7 years ago
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1. Overbosch Paper - "Combined Typhoid Fever and
Hepatitis A vaccine: Comparison of Immunogenicity
and Safety to monovalent vaccine over 3 years".
SUMMARY - BACKGROUND, RESULTS, CONCLUSION
- safety and immunogenicity were compared
with the monovalent up to 1 month and
after a booster dose at 3 years
- healthy adult volunteers GROUP
A=179 GROUP and B=181
- subgroups were boosted after 3
years with Viatim GROUP C=56
and GROUP D=46
- local and systemic reactions were
recorded for 28 days post
vaccination
- seroconversion, seroprotection and
mean antibody concentrations were
measured at at 14, 28 days, 1, 2 and 3
years post vaccination -
- it was again
measured at 28
days post booster
dose
- SEROCONVERSION is the time period during
which a specific antibody develops and
becomes detectable in the blood. After
seroconversion has occurred, the disease can
be detected in blood tests for the antibody.
- SEROPROTECTION: the
protection gained by
vaccination
- MEAN ANTIBODY
CONCENTRATIONS: An
antibody titer is a
measurement of how much
antibody an organism has
produced that recognizes a
particular epitope,
expressed as the inverse of
the greatest dilution (in a
serial dilution) that still
gives a positive result.
ELISA is a common means
of determining antibody
titers.
- it was again
measured at 28
days post booster
dose
- RESULTS
- safety profiles were similar
between 2 groups
- immediate local reactions were
infrequent in GROUP A and B
- reactions were mild
to moderate pain
- less frequent
reactions with
mono hep a
- less frequent
reactions with
mono hep a
- antibody concentration to both antigens
were similar in both GROUPS A & B
- HEP A - Day 28
GROUP A - 98.7%
- HEP A - 3 years
GROUP A - 99.1%
- 100% protection
after booster
- 100% protection
after booster
- HEP A - 3 years
GROUP A - 99.1%
- HEP A - Day 28
GROUP B -100%
- HEP A - 3 years
GROUP B - 99%
- 100% protection
after booster
- 100% protection
after booster
- HEP A - 3 years
GROUP B - 99%
- Ty - Day 28
GROUP A 85.2%
- Ty - 3 years GROUP A
fell to 32.1%
- after booster
increased to 67.3%
- after booster
increased to 67.3%
- Ty - 3 years GROUP A
fell to 32.1%
- Ty - Day 28
GROUP B 84.9%
- Ty - 3 years GROUP B
fell to 35.6%
- after booster
increased to 69.8%
- after booster
increased to 69.8%
- Ty - 3 years GROUP B
fell to 35.6%
- seroprotection rates HEP A
- seroprotection rates TYPHOID
- HEP A - Day 28
GROUP A - 98.7%
- safety profiles were similar
between 2 groups
- CONCLUSION
- combined vaccine Viatim had
equivalent safety and tolerability
compared to monovalent
- combined vaccine was as rapidly
immunogenic as monovalent when
given concurrently
- a booster dose after 3 years significantly
increased antibody levels
- some evidence of
hyporesonsiveness of
the ty response
- combined vaccine Viatim had
equivalent safety and tolerability
compared to monovalent
- BACKGROUND
- The safety and immunogenicity of
Viatim, (combined hep a (HA) and
typhoid (Vi) vaccine were compared
with the monovalent component
vaccine
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